CCR1
CCR1，即趨化因子受體1，別名CCL3受體、CD191。CCR1是一種G蛋白偶聯(lián)受體（GPCR），主要表達(dá)在髓系細(xì)胞如單核細(xì)胞、巨噬細(xì)胞以及某些T細(xì)胞和B細(xì)胞上。CCR1的作用機(jī)制涉及其與配體結(jié)合后，激活G蛋白介導(dǎo)的信號通路，包括磷脂酶C（PLC）和腺苷酸環(huán)化酶（AC）等，導(dǎo)致細(xì)胞內(nèi)鈣離子水平變化、肌醇三磷酸（IP3）產(chǎn)生和cAMP水平變化，進(jìn)而引發(fā)細(xì)胞的趨化運動和功能變化。CCR1在免疫應(yīng)答和炎癥反應(yīng)中發(fā)揮關(guān)鍵作用。它參與免疫細(xì)胞的招募到炎癥部位，促進(jìn)病原體清除和組織修復(fù)。CCR1的功能異常與多種疾病的發(fā)生發(fā)展有關(guān)，包括哮喘、動脈粥樣硬化、多發(fā)性硬化和某些腫瘤。CCR1及其配體的相互作用在疾病的發(fā)病機(jī)制中起著重要作用，并成為潛在的治療靶點。
熱銷產(chǎn)品
Recombinant Human C-C chemokine receptor type 1 (CCR1) (CSB-CF004839HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CCR1 Antibody (CSB-PA004839LA01HU)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA004839LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA004839LA01HU at dilution of 1:100
Immunofluorescent analysis of U251 cells using CSB-PA004839LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CCR1 Antibodies
CCR1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA004839LA01HU | CCR1 Antibody | Human | ELISA, IHC, IF |
CCR1 Proteins
CCR1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004839HU1 CSB-BP004839HU1 CSB-MP004839HU1 CSB-EP004839HU1-B |
Recombinant Human C-C chemokine receptor type 1 (CCR1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004839HU | Recombinant Human C-C chemokine receptor type 1 (CCR1) | in vitro E.coli expression system |
| CSB-EP004839HU1 | Recombinant Human C-C chemokine receptor type 1 (CCR1), partial | E.coli |
CCR1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004839MO1 CSB-EP004839MO1 CSB-BP004839MO1 CSB-MP004839MO1 CSB-EP004839MO1-B |
Recombinant Mouse C-C chemokine receptor type 1 (Ccr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004839MO | Recombinant Mouse C-C chemokine receptor type 1 (Ccr1) | in vitro E.coli expression system |
CCR1 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004839MOW1 CSB-EP004839MOW1 CSB-BP004839MOW1 CSB-MP004839MOW1 CSB-EP004839MOW1-B |
Recombinant Macaca mulatta (Rhesus macaque) C-C chemokine receptor type 1 (CCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004839MOW | Recombinant Macaca mulatta (Rhesus macaque) C-C chemokine receptor type 1 (CCR1) | in vitro E.coli expression system |
CCR1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018378SXV1 CSB-EP018378SXV1 CSB-BP018378SXV1 CSB-MP018378SXV1 CSB-EP018378SXV1-B |
Recombinant Schizosaccharomyces pombe NADPH--cytochrome P450 reductase (ccr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018378SXV | Recombinant Schizosaccharomyces pombe NADPH--cytochrome P450 reductase (ccr1) | in vitro E.coli expression system |
CCR1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP650508MOV CSB-EP650508MOV CSB-BP650508MOV CSB-MP650508MOV CSB-EP650508MOV-B |
Recombinant Macaca fascicularis C-C chemokine receptor type 1 (CCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR1 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP879677DOA CSB-EP879677DOA CSB-BP879677DOA CSB-MP879677DOA CSB-EP879677DOA-B |
Recombinant Arabidopsis thaliana Serine/threonine-protein kinase-like protein CCR1 (CCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
