CCR3
CCR3（C-C趨化因子受體3）是一種主要分布于嗜酸性粒細胞、嗜堿性粒細胞及Th2細胞的G蛋白偶聯受體，也被稱為CD193。該蛋白通過與Eotaxin等趨化因子結合，調控免疫細胞向炎癥部位遷移，尤其在過敏性疾病中扮演核心角色。研究發(fā)現，其在哮喘患者的呼吸道、過敏性鼻炎鼻黏膜及特應性皮炎皮損部位異常活躍，與嗜酸性粒細胞浸潤直接相關。近年還發(fā)現某些實體瘤微環(huán)境中CCR3高表達，可能參與腫瘤免疫逃逸，例如結腸癌中CCR3信號可能促進血管生成。
針對CCR3的藥物研發(fā)曾聚焦于小分子拮抗劑，如GSK766994等早期候選藥物在臨床試驗中因療效不足或脫靶效應未能突破。目前策略轉向聯合療法，例如將CCR3抑制劑與抗IgE抗體奧馬珠單抗聯用，或開發(fā)雙功能抗體同時阻斷CCR3與IL-5通路。2022年跨國藥企公布的臨床前數據顯示，新型變構抑制劑可選擇性抑制嗜酸性粒細胞遷移而不影響其他免疫細胞，為減少副作用提供新方向。但該靶點成藥性挑戰(zhàn)仍存，需進一步驗證其在復雜炎癥網絡中的調控機制。
熱銷產品
CCR3 Antibody (CSB-PA004842LA01HU)
驗證數據
Western Blot
Positive WB detected in: Mouse liver tissue
All lanes: CCR3 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
predicted band size: 42, 44 kDa
observed band size: 42 kDa
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA004842LA01HU at dilution of 1:100
Immunofluorescent analysis of A549 cells using CSB-PA004842LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CCR3 Antibodies
CCR3 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA005330 | CCR3 Antibody | Human | WB, ELISA |
| CSB-PA262645 | CCR3 Antibody | Human | ELISA,WB,IHC |
| CSB-PA793937 | CCR3 Antibody | Human | ELISA,WB,IHC |
| CSB-PA004842LA01HU | CCR3 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA004842LB01HU | CCR3 Antibody, HRP conjugated | Human | ELISA |
CCR3 Proteins
CCR3 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004842HU1 CSB-EP004842HU1 CSB-BP004842HU1 CSB-MP004842HU1 CSB-EP004842HU1-B |
Recombinant Human C-C chemokine receptor type 3 (CCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004842HU | Recombinant Human C-C chemokine receptor type 3 (CCR3) | in vitro E.coli expression system |
| CSB-CF004842HUl3 | Recombinant Human C-C chemokine receptor type 3 (CCR3) | in vitro E.coli expression system |
CCR3 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004842MO1 CSB-EP004842MO1 CSB-BP004842MO1 CSB-MP004842MO1 CSB-EP004842MO1-B |
Recombinant Mouse Probable C-C chemokine receptor type 3 (Ccr3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004842MO | Recombinant Mouse Probable C-C chemokine receptor type 3 (Ccr3) | in vitro E.coli expression system |
CCR3 Proteins for Macaca mulatta (Rhesus macaque)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004842MOW1 CSB-EP004842MOW1 CSB-BP004842MOW1 CSB-MP004842MOW1 CSB-EP004842MOW1-B |
Recombinant Macaca mulatta (Rhesus macaque) C-C chemokine receptor type 3 (CCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004842MOW | Recombinant Macaca mulatta (Rhesus macaque) C-C chemokine receptor type 3 (CCR3) | in vitro E.coli expression system |
CCR3 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004842RA1 CSB-EP004842RA1 CSB-BP004842RA1 CSB-MP004842RA1 CSB-EP004842RA1-B |
Recombinant Rat C-C chemokine receptor type 3 (Ccr3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004842RA | Recombinant Rat C-C chemokine receptor type 3 (Ccr3) | in vitro E.coli expression system |
CCR3 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004842DSU1 CSB-EP004842DSU1 CSB-BP004842DSU1 CSB-MP004842DSU1 CSB-EP004842DSU1-B |
Recombinant Chlorocebus aethiops C-C chemokine receptor type 3 (CCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004842DSU | Recombinant Chlorocebus aethiops C-C chemokine receptor type 3 (CCR3) | in vitro E.coli expression system |
CCR3 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP714527DO1 CSB-EP714527DO1 CSB-BP714527DO1 CSB-MP714527DO1 CSB-EP714527DO1-B |
Recombinant Dog C-C chemokine receptor type 3 (CCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF714527DO | Recombinant Dog C-C chemokine receptor type 3 (CCR3) | in vitro E.coli expression system |
CCR3 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP858985MOV1 CSB-EP858985MOV1 CSB-BP858985MOV1 CSB-MP858985MOV1 CSB-EP858985MOV1-B |
Recombinant Macaca fascicularis C-C chemokine receptor type 3 (CCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF858985MOV | Recombinant Macaca fascicularis C-C chemokine receptor type 3 (CCR3) | in vitro E.coli expression system |
CCR3 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP878633DOA CSB-EP878633DOA CSB-BP878633DOA CSB-MP878633DOA CSB-EP878633DOA-B |
Recombinant Arabidopsis thaliana Putative serine/threonine-protein kinase-like protein CCR3 (CCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
