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CCR4

CCR4:Treg細胞上的關(guān)鍵趨化因子受體,有望成為新型腫瘤免疫治療靶點!

C-C趨化因子受體(C-C chemokine receptor type 4,CCR4),也稱為CD194,由包含7次跨膜結(jié)構(gòu)域的多肽鏈組成,屬于G蛋白偶聯(lián)受體家族。其含360個氨基酸,分子量約為41kD,主要表達于各種淋巴細胞和組織,其配體包括多種趨化因子。作為重要的趨化因子受體,CCR4與其它趨化因子配體產(chǎn)生結(jié)合,行使其功能,參與調(diào)控人類自身免疫疾病過程,主要包括特應(yīng)性皮炎、哮喘、皮膚T細胞淋巴瘤。過去,研究人員對趨化因子的認識限于在炎癥反應(yīng)中的趨化作用,然而越來越多的研究顯示,趨化因子結(jié)合其受體在腫瘤細胞的浸潤性生長,遠處轉(zhuǎn)移等行為中發(fā)揮重要作用。CCR4作為腫瘤轉(zhuǎn)移中關(guān)鍵的趨化因子受體,多項研究已證實,CCR4高表達與血液系統(tǒng)腫瘤以及惡性實體瘤的浸潤和預(yù)后密切相關(guān),靶向CCR4有望成為惡性腫瘤免疫治療的新策略。

CUSABIO-哺乳包膜VLPs平臺成功開發(fā)CCR4全長膜蛋白(7次跨膜),展示了完整生物活性。


熱銷產(chǎn)品

Recombinant Human C-C chemokine receptor type 4 (CCR4)-VLPs (Active) (CSB-MP004843HU)

驗證數(shù)據(jù)

CSB-MP004843HU

CSB-MP004843HU is detected by Mouse anti-6*His monoclonal antibody.

CSB-MP004843HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CCR4 at 10 μg/ml can bind Anti-CCR4 recombinant antibody(CSB-RA004843MA01HU), the EC50 is 362.3-630.8 ng/mL.

CSB-MP004843HU

The presence of VLP-like structures was confirmed by TEM

Recombinant Human C-C chemokine receptor type 4 (CCR4) (Active) (CSB-CF004843HU)

驗證數(shù)據(jù)

CSB-CF004843HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-CF004843HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CCR4 at 5 μg/ml can bind Anti-CCR4 recombinant antibody (CSB-RA004843MA01HU). The EC50 is 2.803-3.369 ng/mL.

CSB-CF004843HU

Activity
Human CCR4 Full Length Protein captured on CM5 chip can bind Human CCR4 Monoclonal Antibody (CSB-RA004843MA01HU) with an affinity constant of 3.16 nM as detected by SPR Assay(Biacore T200).

CSB-CF004843HU

Activity
Human CCR4 Monoclonal Antibody (CSB-RA004843MA01HU) captured on Protein A Chip can bind Human CCR4 Full Length Protein with an affinity constant of 1.71 nM as detected by MetaSPR Assay (in presence of FOS-12)(WeSPRTM 200) .

CCR4 Antibodies

CCR4 for Homo sapiens (Human)

CCR4 Proteins

CCR4 Proteins for Homo sapiens (Human)

CCR4 Proteins for Mus musculus (Mouse)

CCR4 Proteins for Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)

CCR4 Proteins for Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)

CCR4 Proteins for Aspergillus niger (strain CBS 513.88 / FGSC A1513)

CCR4 Proteins for Enterocytozoon bieneusi (strain H348) (Microsporidian parasite)

CCR4 Proteins for Nosema ceranae (strain BRL01) (Microsporidian parasite)

CCR4 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

CCR4 Proteins for Aspergillus terreus (strain NIH 2624 / FGSC A1156)

CCR4 Proteins for Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)

CCR4 Proteins for Coccidioides immitis (strain RS) (Valley fever fungus)

CCR4 Proteins for Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

CCR4 Proteins for Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)

CCR4 Proteins for Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

CCR4 Proteins for Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)

CCR4 Proteins for Ustilago maydis (strain 521 / FGSC 9021) (Smut fungus)

CCR4 Proteins for Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)

CCR4 Proteins for Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

CCR4 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)

CCR4 Proteins for Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)

CCR4 Proteins for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)

CCR4 Proteins for Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)

CCR4 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

CCR4 Proteins for Arabidopsis thaliana (Mouse-ear cress)

CCR4 Proteins for Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)