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CD276

CD276,別名B7H3、B7-H3、4Ig-B7-H3,是一種I型跨膜蛋白,屬于B7家族成員之一,主要表達(dá)于抗原呈遞細(xì)胞表面。
其作用機(jī)制涉及與T細(xì)胞共刺激分子家族成員相互作用,激活或抑制T細(xì)胞的活化與增殖。CD276既可以作為共刺激因子促進(jìn)T細(xì)胞激活、增殖和細(xì)胞因子分泌,也可能在某些適應(yīng)性免疫應(yīng)答中起到共抑制作用,使腫瘤逃避免疫反應(yīng)和抑制NK細(xì)胞介導(dǎo)的細(xì)胞裂解。
CD276在多種腫瘤中表達(dá),并與腫瘤的發(fā)生、侵襲和轉(zhuǎn)移有關(guān),是一種重要的免疫檢查點(diǎn)分子和潛在的腫瘤免疫治療靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human CD276 antigen (CD276), partial (Active) (CSB-MP733578HU)

驗(yàn)證數(shù)據(jù)

CSB-MP733578HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP733578HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized CD276 at 2 μg/ml can bind Anti-CD276 rabbit monoclonal antibody, the EC50 of human CD276 protein is 1.961-2.243 ng/ml.

Recombinant Macaca fascicularis CD276 molecule(CD276),partial (Active) (CSB-MP5140MOV)

驗(yàn)證數(shù)據(jù)

CSB-MP5140MOV

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP5140MOV

Activity
Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus CD276 at 2 μg/ml can bind Anti-CD276 recombinant antibody(CSB-RA733578MA1HU). The EC50 is 4.299-5.373 ng/mL.

CSB-MP5140MOV

The purity of CD276 was greater than 90% as determined by SEC-HPLC

CD276 Recombinant Monoclonal Antibody (CSB-RA733578MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA733578MA1HU

The Binding Activity of Human CD276 with Anti-CD276 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized human CD276(CSB-MP5140MOV) at 2 μg/mL can bind Anti-CD276 recombinant antibody. The EC50 is 4.299-5.373 ng/mL.

CSB-RA733578MA1HU

The Binding Activity of Human CD276 with Anti-CD276 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized human CD276(CSB-MP733578HU(F2)) at 2 μg/mL can bind Anti-CD276 recombinant antibody. The EC50 is 47.12-54.16 ng/mL.

CSB-RA733578MA1HU

Overlay Peak curve showing MCF7 cells stained with CSB-RA733578MA1HUMA1HU (red line) at 1:100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

CD276 Antibodies

CD276 for Homo sapiens (Human)

CD276 Proteins

CD276 Proteins for Xenopus laevis (African clawed frog)

CD276 Proteins for Homo sapiens (Human)

CD276 Proteins for Rattus norvegicus (Rat)

CD276 Proteins for Mus musculus (Mouse)

CD276 ELISA Kit

CD276 ELISA Kit for Homo sapiens (Human)