CD3E

CD3E，即T細胞受體復合物的CD3ε亞基，它是一種在T細胞表面表達的糖蛋白，由CD3E基因編碼。CD3E是T細胞受體（TCR）信號傳導復合物的一部分，與TCRαβ或TCRγδ亞單位非共價結合。其作用機制是在T細胞受體識別并結合到主要組織相容性復合物（MHC）呈遞的抗原肽時，CD3E與其他CD3分子協同，傳遞激活信號，導致T細胞的激活。信號通路涉及酪氨酸激酶的激活，如ζ鏈相關蛋白激酶76（ZAP-70），進而激活下游的多種信號分子，包括磷脂酰肌醇3激酶（PI3K）、蛋白激酶C（PKC）和絲裂原激活蛋白激酶（MAPK）。這些信號通路最終導致T細胞增殖、分化和效應功能的發(fā)展。在生物學意義上，CD3E對T細胞介導的免疫應答至關重要，它參與調節(jié)細胞毒性T細胞和輔助T細胞的激活，對清除病原體、抗腫瘤免疫以及自身免疫反應的調控具有重要作用。CD3E的功能異?？赡芘c某些免疫缺陷和自身免疫疾病相關。

熱銷產品

Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial (CSB-MP004931HU)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

The purity of CD3E was greater than 90% as determined by SEC-HPLC

CD3E Recombinant Monoclonal Antibody (CSB-RA004931MA1HU)

驗證數據

Overlay Peak curve showing JK cells surface stained with CSB-RA004931MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*10⁶cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*10⁶cells) used under the same conditions. Acquisition of >10, 006 events was performed.

CD3E Antibody

CD3E Protein

CD3E Antibodies

CD3E for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA10484A0Rb	CD3E Antibody	Human	ELISA, WB, IHC, IF
CSB-PA10484C0Rb	CD3E Antibody, FITC conjugated	Human
CSB-PA004931GA01HU	CD3E Antibody	Human	ELISA,WB,IHC
CSB-PA949010	CD3E Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA005833	CD3E Antibody	Human	WB, ELISA
CSB-PA070244	CD3E Antibody	Human	WB, IHC, ELISA
CSB-PA004931HA01HU	CD3E Antibody	Human	ELISA, IHC, IF
CSB-PA004931HB01HU	CD3E Antibody, HRP conjugated	Human	ELISA
CSB-PA004931HC01HU	CD3E Antibody, FITC conjugated	Human
CSB-PA004931HD01HU	CD3E Antibody, Biotin conjugated	Human	ELISA
CSB-RA004931MA1HU	CD3E Recombinant Monoclonal Antibody	Human	ELISA, FC

CD3E Proteins

CD3E Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP004931MO	Recombinant Mouse T-cell surface glycoprotein CD3 epsilon chain (Cd3e), partial	Yeast
CSB-BP004931MO CSB-MP004931MO CSB-EP004931MO-B	Recombinant Mouse T-cell surface glycoprotein CD3 epsilon chain (Cd3e), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP004931MO	Recombinant Mouse T-cell surface glycoprotein CD3 epsilon chain (Cd3e), partial	E.coli
CSB-EP004931MOc7	Recombinant Mouse T-cell surface glycoprotein CD3 epsilon chain (Cd3e), partial	E.coli

CD3E Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產品貨號	產品名稱	來源
CSB-YP004931DO1 CSB-EP004931DO1 CSB-BP004931DO1 CSB-MP004931DO1 CSB-EP004931DO1-B	Recombinant Dog T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004931DO	Recombinant Dog T-cell surface glycoprotein CD3 epsilon chain (CD3E)	in vitro E.coli expression system

CD3E Proteins for Ovis aries (Sheep)

產品貨號	產品名稱	來源
CSB-YP004931SH1 CSB-EP004931SH1 CSB-BP004931SH1 CSB-MP004931SH1 CSB-EP004931SH1-B	Recombinant Sheep T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004931SH	Recombinant Sheep T-cell surface glycoprotein CD3 epsilon chain (CD3E)	in vitro E.coli expression system

CD3E Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP004931HU	Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial	Yeast
CSB-EP004931HU(A4)	Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E)	E.coli
CSB-CF004931HU	Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E)	in vitro E.coli expression system
CSB-EP004931HU	Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial	E.coli
CSB-BP004931HU CSB-EP004931HU-B	Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial	Baculovirus In Vivo Biotinylation in E.coli
CSB-MP004931HU	Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial	Mammalian cell

CD3E Proteins for Bos taurus (Bovine)

產品貨號	產品名稱	來源
CSB-YP637748BO CSB-EP637748BO CSB-BP637748BO CSB-MP637748BO CSB-EP637748BO-B	Recombinant Bovine T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD3E Proteins for Felis catus (Cat) (Felis silvestris catus)

產品貨號	產品名稱	來源
CSB-YP725239CA CSB-EP725239CA CSB-BP725239CA CSB-MP725239CA CSB-EP725239CA-B	Recombinant Cat T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD3E Proteins for Sus scrofa (Pig)

產品貨號	產品名稱	來源
CSB-YP801781PI CSB-BP801781PI CSB-MP801781PI CSB-EP801781PI-B	Recombinant Pig T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD3E Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

產品貨號	產品名稱	來源
CSB-YP822100MOV CSB-EP822100MOV CSB-BP822100MOV CSB-MP822100MOV CSB-EP822100MOV-B	Recombinant Macaca fascicularis T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD3E Proteins for Gallus gallus (Chicken)

產品貨號	產品名稱	來源
CSB-YP822537CH CSB-EP822537CH CSB-BP822537CH CSB-MP822537CH CSB-EP822537CH-B	Recombinant Chicken T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD3E Proteins for Oryctolagus cuniculus (Rabbit)

產品貨號	產品名稱	來源
CSB-YP890601RB CSB-EP890601RB CSB-BP890601RB CSB-MP890601RB CSB-EP890601RB-B	Recombinant Rabbit T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli