CD3G

CD3γ鏈是T細胞受體復(fù)合物的核心組成單元，常被簡稱為CD3γ或T3G。它與CD3δ、CD3ε等亞基共同形成跨膜蛋白簇，協(xié)助T細胞識別抗原信號并啟動免疫應(yīng)答。該蛋白在胸腺細胞發(fā)育中不可或缺，其功能缺陷可導(dǎo)致重癥聯(lián)合免疫缺陷病（SCID），表現(xiàn)為反復(fù)感染和免疫系統(tǒng)崩潰。CD3γ的異常表達還與T細胞淋巴瘤、系統(tǒng)性紅斑狼瘡等疾病存在關(guān)聯(lián)。在治療領(lǐng)域，基于CD3靶點的雙特異性抗體藥物已取得突破性進展，例如貝林妥歐單抗通過同時結(jié)合CD3與腫瘤抗原，可引導(dǎo)T細胞精準殺傷惡性細胞，目前已獲批用于白血病臨床治療。此外，利用CD3γ構(gòu)建的CAR-T療法在實體瘤研究中展現(xiàn)出潛力，部分項目已進入Ⅱ期臨床試驗。

熱銷產(chǎn)品

Recombinant Human T-cell surface glycoprotein CD3 gamma chain (CD3G), partial (CSB-EP004933HU1)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CD3G Antibody (CSB-PA004933LA01HU)

驗證數(shù)據(jù)

Western Blot
Positive WB detected in: MCF-7 whole cell lysate, HEK293 whole cell lysate, NIH/3T3 whole cell lysate, Rat stomach tissue
All lanes: CD3G antibody at 2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 21 kDa
Observed band size: 21 kDa

Immunofluorescent analysis of HepG2 cells using CSB-PA004933LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

CD3G Antibody

CD3G Protein

CD3G Antibodies

CD3G for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA004933GA01HU	CD3G Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA004933LA01HU	CD3G Antibody	Human, Mouse, Rat	ELISA, WB, IF
CSB-PA004933LD01HU	CD3G Antibody, Biotin conjugated	Human	ELISA

CD3G Proteins

CD3G Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004933MO1 CSB-EP004933MO1 CSB-BP004933MO1 CSB-MP004933MO1 CSB-EP004933MO1-B	Recombinant Mouse T-cell surface glycoprotein CD3 gamma chain (Cd3g), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004933MO	Recombinant Mouse T-cell surface glycoprotein CD3 gamma chain (Cd3g)	in vitro E.coli expression system

CD3G Proteins for Ovis aries (Sheep)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004933SH CSB-EP004933SH CSB-BP004933SH CSB-MP004933SH CSB-EP004933SH-B	Recombinant Sheep T-cell surface glycoprotein CD3 gamma chain (CD3G), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD3G Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004933HU1 CSB-BP004933HU1 CSB-EP004933HU1-B	Recombinant Human T-cell surface glycoprotein CD3 gamma chain (CD3G), partial	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-CF004933HU	Recombinant Human T-cell surface glycoprotein CD3 gamma chain (CD3G)	in vitro E.coli expression system
CSB-EP004933HU1	Recombinant Human T-cell surface glycoprotein CD3 gamma chain (CD3G), partial	E.coli
CSB-MP004933HU1	Recombinant Human T-cell surface glycoprotein CD3 gamma chain (CD3G), partial	Mammalian cell

CD3G Proteins for Bos taurus (Bovine)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP636709BO CSB-EP636709BO CSB-BP636709BO CSB-MP636709BO CSB-EP636709BO-B	Recombinant Bovine T-cell surface glycoprotein CD3 gamma chain (CD3G), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD3G Proteins for Sus scrofa (Pig)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP735566PI CSB-EP735566PI CSB-BP735566PI CSB-MP735566PI CSB-EP735566PI-B	Recombinant Pig T-cell surface glycoprotein CD3 gamma chain (CD3G), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD3G Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP737336RA CSB-EP737336RA CSB-BP737336RA CSB-MP737336RA CSB-EP737336RA-B	Recombinant Rat T-cell surface glycoprotein CD3 gamma chain (Cd3g), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD3G Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP850179MOV	Recombinant Macaca fascicularis T-cell surface glycoprotein CD3 gamma chain (CD3G), partial	Yeast
CSB-EP850179MOV CSB-BP850179MOV CSB-MP850179MOV CSB-EP850179MOV-B	Recombinant Macaca fascicularis T-cell surface glycoprotein CD3 gamma chain (CD3G), partial	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli