CD40LG
CD40配體(CD40LG/CD154/TNFSF5)是CD40的天然三聚體配體，是一種39kDa的II型膜糖蛋白，其在多種細(xì)胞類型上表達(dá)，包括活化的CD4+T細(xì)胞、活化的B細(xì)胞、記憶CD8+T細(xì)胞、激活的自然殺傷細(xì)胞、粒細(xì)胞、內(nèi)皮細(xì)胞、平滑肌細(xì)胞、巨噬細(xì)胞和活化血小板。CD40是在各種免疫細(xì)胞（如B細(xì)胞、樹(shù)突細(xì)胞和巨噬細(xì)胞）上表達(dá)的受體蛋白。CD40L可與CD40相互作用，觸發(fā)這些免疫細(xì)胞的過(guò)度刺激，導(dǎo)致免疫反應(yīng)級(jí)聯(lián)和介導(dǎo)炎癥的過(guò)度生產(chǎn)，從而導(dǎo)致很多自身免疫性疾病。因此，靶向CD40L，阻斷CD40L與CD40和其他結(jié)合位點(diǎn)的相互作用，可潛在的降低自身免疫和炎癥反應(yīng)。針對(duì)CD40L開(kāi)發(fā)的藥物，可用于治療自身免疫性疾病，比如視神經(jīng)脊髓炎（NMOSD）、重癥肌無(wú)力和lgG4相關(guān)疾病，干燥綜合征以及腎移植脫敏等等。
Recombinant Human CD40LG 活性蛋白實(shí)驗(yàn)驗(yàn)證數(shù)據(jù)
SDS-PAGE
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized CD40L at 2 μg/ml can bind Anti- CD40L Rabbit Monoclonal Antibody(CSB-RA156386A0HU), the EC50 is 2.353-3.232 ng/ml.
Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay.
CD40LG Antibodies
CD40LG for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA004937GA01HU | CD40LG Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA06005A0Rb | CD40LG Antibody | Human | ELISA |
| CSB-PA06005B0Rb | CD40LG Antibody, HRP conjugated | Human | ELISA |
| CSB-PA067336 | CD40LG Antibody | Human,Mouse | ELISA,WB |
CD40LG Proteins
CD40LG Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-EP004937MO1 CSB-BP004937MO1 CSB-EP004937MO1-B |
Recombinant Mouse CD40 ligand (Cd40lg), partial | E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF004937MO | Recombinant Mouse CD40 ligand (Cd40lg) | in vitro E.coli expression system |
CD40LG Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004937HU1 | Recombinant Human CD40 ligand (CD40LG), partial | Yeast |
| CSB-EP004937HU4 | Recombinant Human CD40 ligand (CD40LG), partial | E.coli |
| CSB-AP002211HU | Recombinant Human CD40 ligand (CD40LG), partial (Active) | E.Coli |
| CSB-CF004937HU | Recombinant Human CD40 ligand (CD40LG) | in vitro E.coli expression system |
| CSB-EP004937HU1 CSB-BP004937HU1 CSB-MP004937HU1 CSB-EP004937HU1-B |
Recombinant Human CD40 ligand (CD40LG), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP005191HU | Recombinant Human CD40 ligand (CD40LG), partial (Active) | E.coli |
| CSB-MP004937HU3 | Recombinant Human CD40 ligand (CD40LG), partial (Active) | Mammalian cell |
| CSB-MP004937HU3-B | Recombinant Human CD40 ligand (CD40LG), partial, Biotinylated | Mammalian cell |
| CSB-EP004937HU1a0 | Recombinant Human CD40 ligand (CD40LG), partial | E.coli |
CD40LG Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004937MOW CSB-BP004937MOW CSB-MP004937MOW CSB-EP004937MOW-B |
Recombinant Macaca mulatta (Rhesus macaque) CD40 ligand (CD40LG), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP004937MOW | Recombinant Macaca mulatta CD40 ligand (CD40LG), partial | E.coli |
CD40LG Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004937CA1 CSB-EP004937CA1 CSB-BP004937CA1 CSB-MP004937CA1 CSB-EP004937CA1-B |
Recombinant Cat CD40 ligand (CD40LG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004937CA | Recombinant Cat CD40 ligand (CD40LG) | in vitro E.coli expression system |
CD40LG Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004937DO1 CSB-EP004937DO1 CSB-BP004937DO1 CSB-MP004937DO1 CSB-EP004937DO1-B |
Recombinant Dog CD40 ligand (CD40LG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004937DO | Recombinant Dog CD40 ligand (CD40LG) | in vitro E.coli expression system |
CD40LG Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004937DRI1 CSB-EP004937DRI1 CSB-BP004937DRI1 CSB-MP004937DRI1 CSB-EP004937DRI1-B |
Recombinant Cercocebus atys CD40 ligand (CD40LG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004937DRI | Recombinant Cercocebus atys CD40 ligand (CD40LG) | in vitro E.coli expression system |
CD40LG Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004937PI CSB-EP004937PI CSB-BP004937PI CSB-MP004937PI CSB-EP004937PI-B |
Recombinant Pig CD40 ligand (CD40LG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD40LG Proteins for Aotus trivirgatus (Night monkey) (Douroucouli)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004937DNI CSB-EP004937DNI CSB-BP004937DNI CSB-MP004937DNI CSB-EP004937DNI-B |
Recombinant Aotus trivirgatus CD40 ligand (CD40LG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD40LG Proteins for Callithrix jacchus (White-tufted-ear marmoset)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004937CYL CSB-EP004937CYL CSB-BP004937CYL CSB-MP004937CYL CSB-EP004937CYL-B |
Recombinant Callithrix jacchus CD40 ligand (CD40LG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD40LG Proteins for Macaca nemestrina (Pig-tailed macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004937MOX CSB-EP004937MOX CSB-BP004937MOX CSB-MP004937MOX CSB-EP004937MOX-B |
Recombinant Macaca nemestrina CD40 ligand (CD40LG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD40LG Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004937CH CSB-EP004937CH CSB-BP004937CH CSB-MP004937CH CSB-EP004937CH-B |
Recombinant Chicken CD40 ligand (CD40LG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD40LG Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004937RA CSB-EP004937RA CSB-BP004937RA CSB-MP004937RA CSB-EP004937RA-B |
Recombinant Rat CD40 ligand (Cd40lg), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD40LG ELISA Kit
CD40LG ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04716h | Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
CD40LG ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04717m | Mouse Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | serum, plasma, tissue homogenates, cell culture supernates. | 0.274 ng/ml. |
CD40LG ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E07395r | Rat Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | serum, plasma, tissue homogenates | 0.47 ng/mL |
