CD46
CD46為一種單鏈跨膜糖蛋白，屬于補(bǔ)體活化調(diào)節(jié)蛋白因子家族。CD46在細(xì)胞表面分布很廣，大多數(shù)正常細(xì)胞上都有CD46表達(dá)，包括造血細(xì)胞系、成纖維細(xì)胞、表皮細(xì)胞、內(nèi)皮細(xì)胞及星狀膠質(zhì)細(xì)胞等，但不同類型的細(xì)胞上表達(dá)的數(shù)量有所不同。大量研究表明CD46可以調(diào)節(jié)T細(xì)胞免疫力，特別是能夠控制炎癥。多項(xiàng)研究已證明CD46與多種免疫炎性疾病相關(guān)，在多發(fā)性硬化疾病過程中，缺乏CD46會(huì)影響T細(xì)胞的增殖與分化，從而導(dǎo)致抗炎癥因子IL-10分泌減少。類風(fēng)濕關(guān)節(jié)炎患者的關(guān)節(jié)液和外周血中中性粒細(xì)胞里CD46高表達(dá)。另外，CD46的表達(dá)在腫瘤逃逸、缺血再灌注中也有明顯變化。因此，CD46可抑制補(bǔ)體系統(tǒng)活化從而減輕免疫反應(yīng)以及通過調(diào)節(jié)T細(xì)胞從而影響抗炎因子的生成，最終影響炎性反應(yīng)。
Recombinant Human CD46 活性蛋白實(shí)驗(yàn)驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized CD46 at 2 μg/ml can bind Anti-CD46 rabbit monoclonal antibody, the EC50 of human CD46 protein is 0.8333-1.054 ng/ml.
CD46 Antibodies
CD46 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA004939GA01HU | CD46 Antibody | Human | ELISA,WB |
| CSB-PA004939EA01HU | CD46 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA004939EB01HU | CD46 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA004939EC01HU | CD46 Antibody, FITC conjugated | Human | |
| CSB-PA930156 | CD46 Antibody | Human | ELISA,IHC |
| CSB-PA923298 | CD46 Antibody | Human | ELISA,IHC |
| CSB-RA908548A0HU | CD46 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
CD46 for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA004939LA01MO | Cd46 Antibody | Mouse | ELISA, WB, IHC |
CD46 Proteins
CD46 Proteins for Cavia porcellus (Guinea pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004939GU CSB-BP004939GU CSB-MP004939GU CSB-EP004939GU-B |
Recombinant Guinea pig Membrane cofactor protein (CD46), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP004939GU | Recombinant Cavia porcellus Membrane cofactor protein (CD46), partial | E.coli |
| CSB-CF004939GU | Recombinant Guinea pig Membrane cofactor protein (CD46) | in vitro E.coli expression system |
CD46 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004939PI1 CSB-EP004939PI1 CSB-BP004939PI1 CSB-MP004939PI1 CSB-EP004939PI1-B |
Recombinant Pig Membrane cofactor protein (CD46), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004939PI | Recombinant Pig Membrane cofactor protein (CD46) | in vitro E.coli expression system |
CD46 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004939MO CSB-BP004939MO CSB-MP004939MO CSB-EP004939MO-B |
Recombinant Mouse Membrane cofactor protein (Cd46), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP004939MO | Recombinant Mouse Membrane cofactor protein (Cd46), partial | E.coli |
| CSB-CF004939MO | Recombinant Mouse Membrane cofactor protein (Cd46) | in vitro E.coli expression system |
CD46 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004939DSU1 CSB-EP004939DSU1 CSB-BP004939DSU1 CSB-MP004939DSU1 CSB-EP004939DSU1-B |
Recombinant Chlorocebus aethiops Membrane cofactor protein (CD46), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004939DSU | Recombinant Chlorocebus aethiops Membrane cofactor protein (CD46) | in vitro E.coli expression system |
CD46 Proteins for Saguinus mystax (Moustached tamarin)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004939SWA CSB-EP004939SWA CSB-BP004939SWA CSB-MP004939SWA CSB-EP004939SWA-B |
Recombinant Saguinus mystax Membrane cofactor protein (CD46) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD46 Proteins for Saimiri sciureus (Common squirrel monkey)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004939SWD CSB-EP004939SWD CSB-BP004939SWD CSB-MP004939SWD CSB-EP004939SWD-B |
Recombinant Saimiri sciureus Membrane cofactor protein (CD46) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD46 Proteins for Saguinus oedipus (Cotton-top tamarin)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004939SWB1 CSB-EP004939SWB1 CSB-BP004939SWB1 CSB-MP004939SWB1 CSB-EP004939SWB1-B |
Recombinant Saguinus oedipus Membrane cofactor protein (CD46), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004939SWB | Recombinant Saguinus oedipus Membrane cofactor protein (CD46) | in vitro E.coli expression system |
CD46 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP735647PYX CSB-EP735647PYX CSB-BP735647PYX CSB-MP735647PYX CSB-EP735647PYX-B |
Recombinant Pongo abelii Membrane cofactor protein (CD46), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD46 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP740933BO CSB-EP740933BO CSB-BP740933BO CSB-MP740933BO CSB-EP740933BO-B |
Recombinant Bovine Membrane cofactor protein (CD46), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD46 Proteins for Callithrix jacchus (White-tufted-ear marmoset)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP808496CYL CSB-EP808496CYL CSB-BP808496CYL CSB-MP808496CYL CSB-EP808496CYL-B |
Recombinant Callithrix jacchus Membrane cofactor protein (CD46), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD46 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-CF004939HU | Recombinant Human Membrane cofactor protein (CD46) | in vitro E.coli expression system |
| CSB-MP004939HU | Recombinant Human Membrane cofactor protein (CD46), partial (Active) | Mammalian cell |
| CSB-EP004939HU1 | Recombinant Human Membrane cofactor protein (CD46), partial | E.coli |
| CSB-MP004939HUc7 | Recombinant Human Membrane cofactor protein (CD46), partial | Mammalian cell |
| CSB-MP004939HU-B | Recombinant Human Membrane cofactor protein (CD46), partial, Biotinylated | Mammalian cell |
CD46 ELISA Kit
CD46 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09216h | Human membrane cofactor protein,MCP ELISA Kit | serum, plasma, tissue homogenates | 0.78 ng/mL |
