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CD47

CD47,白細胞表面抗原 CD47,也被稱為整合素相關蛋白(IAP)或MER6蛋白。CD47屬于免疫球蛋白超家族成員,廣泛表達于多種細胞表面,由人類CD47基因編碼。CD47的作用機制主要涉及與信號調節(jié)蛋白α的相互作用,通過磷酸化激活SIRPα,招募和激活SHP磷酸酶,進而介導肌球蛋白2a去磷酸化,導致巨噬細胞對攜帶CD47的細胞的吞噬作用減弱,從而負調節(jié)吞噬作用。CD47在維持良性細胞的免疫耐受中起著關鍵作用,確保自體細胞不會被不適當?shù)赝淌?。然而,許多不同類型的癌癥細胞利用CD47的高表達來介導免疫逃逸,逃避被巨噬細胞吞噬的命運。CD47的阻斷劑正在被開發(fā)用于促進巨噬細胞吞噬腫瘤細胞,作為癌癥治療的潛在策略。

熱銷產品

Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) (CSB-MP004940HU)

驗證數(shù)據(jù)

CSB-MP004940HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP004940HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized SIRPA (CSB-MP021334HU) at 2 μg/ml can bind human CD47, the EC50 of human CD47 protein is 65.91-82.42 ng/ml.

CSB-MP004940HU

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

CD47 (Magrolimab) Recombinant Monoclonal Antibody (CSB-RA004940MA1HU)

驗證數(shù)據(jù)

CSB-RA004940MA1HU

The Binding Activity of Human CD47 with Anti-CD47 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD47 (CSB-MP004940HUd7) at 2 μg/mL can bind Anti-CD47 recombinant antibody. The EC50 is 1.343-1.561 ng/mL.

CSB-RA004940MA1HU

Untransfected CT26 cells (green line) and transfected Human DLL3 & CD47 CT26 stable cells (red line) were stained with anti-CD47 antibody (CSB-RA004940MA1HU) (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-RA004940MA1HU

Untransfected CT26 cells (green line) and transfected Human DLL3 & CD47 CT26 stable cells (red line) were stained with anti-DLL3 antibody (CSB-RA882142MA2HU) (2μg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CD47 Antibodies

CD47 for Homo sapiens (Human)

CD47 Proteins

CD47 Proteins for Rattus norvegicus (Rat)

CD47 Proteins for Mus musculus (Mouse)

CD47 Proteins for Pongo abelii (Sumatran orangutan)

CD47 Proteins for Sus scrofa (Pig)

CD47 Proteins for Bos taurus (Bovine)

CD47 Proteins for Homo sapiens (Human)

CD47 ELISA Kit

CD47 ELISA Kit for Homo sapiens (Human)

CD47 ELISA Kit for Mus musculus (Mouse)