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CD55

CD55,也被稱為衰變加速因子(DAF),是一種重要的補(bǔ)體調(diào)節(jié)蛋白,在人體內(nèi)發(fā)揮著關(guān)鍵的免疫保護(hù)作用。它屬于RCA(補(bǔ)體激活調(diào)節(jié)蛋白)家族,含有4到30個(gè)短共識(shí)重復(fù)(SCR)結(jié)構(gòu)域,通過(guò)這些結(jié)構(gòu)域參與多種生物過(guò)程。CD55主要通過(guò)抑制補(bǔ)體系統(tǒng)的激活來(lái)保護(hù)細(xì)胞免受攻擊。它能夠識(shí)別補(bǔ)體系統(tǒng)產(chǎn)生的C3b和C4b片段,通過(guò)與C4b結(jié)合抑制C2轉(zhuǎn)化為C2b,進(jìn)而阻止C4b2a形成C3轉(zhuǎn)化酶,從而抑制C3轉(zhuǎn)化酶的形成。在替代途徑中,CD55與C3b結(jié)合后可以干擾D因子將B因子轉(zhuǎn)化為Bb,同樣阻止膜攻擊復(fù)合物的形成。CD55的這些作用機(jī)制有效地防止了補(bǔ)體級(jí)聯(lián)反應(yīng)的過(guò)度激活,保護(hù)細(xì)胞免受補(bǔ)體攻擊。此外,CD55還參與腫瘤的發(fā)生發(fā)展,在多種癌癥中高表達(dá),如前列腺癌、宮頸癌、乳腺癌等。CD55與CD97結(jié)合形成的復(fù)合物在腫瘤細(xì)胞的分化、遷移、浸潤(rùn)及轉(zhuǎn)移中發(fā)揮重要作用?;贑D55在免疫系統(tǒng)和腫瘤生物學(xué)中的重要作用,CD55和CD97成為癌癥治療研究的新興靶點(diǎn)。目前,已有多種靶向CD55和CD97的藥物正在研發(fā)中,如CD55抗體可用于抑制結(jié)直腸癌和肺癌的惡化,CD55相關(guān)信號(hào)通路的抑制可增強(qiáng)其他治療藥物的抗腫瘤作用。此外,針對(duì)CD55缺乏蛋白丟失性腸病(CHAPLE?。┑闹委熕幬镆苍谘邪l(fā)中,如FDA已批準(zhǔn)的新藥Veopoz,它是一種C5補(bǔ)體抑制劑,能靶向參與補(bǔ)體系統(tǒng)激活的蛋白質(zhì)補(bǔ)體因子C5,預(yù)防補(bǔ)體途徑介導(dǎo)的CHAPLE病。

熱銷產(chǎn)品

Recombinant Human Complement decay-accelerating factor (CD55), partial (CSB-EP004945HU1)

驗(yàn)證數(shù)據(jù)

CSB-EP004945HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CD55 Recombinant Monoclonal Antibody (CSB-RA440943A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA440943A0HU

Western Blot
Positive WB detected in: A549 whole cell lysate, 293T whole cell lysate, K562 whole cell lysate
All lanes: CD55 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 42, 49, 40, 57, 60 kDa
Observed band size: 70 kDa

CSB-RA440943A0HU

IHC image of CSB-RA440943A0HU diluted at 1:100 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA440943A0HU

IHC image of CSB-RA440943A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Human decay-accelerating factor(DAF/CD55)ELISA Kit (CSB-E05121h)

驗(yàn)證數(shù)據(jù)

CSB-E05121h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E05121h

規(guī)格:96T/48T

靈敏度:0.09 ng/ml

檢測(cè)范圍:0.39 ng/ml- 25ng/ml

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CD55 Antibodies

CD55 for Homo sapiens (Human)

CD55 Proteins

CD55 Proteins for Homo sapiens (Human)

CD55 Proteins for Pongo pygmaeus (Bornean orangutan)

CD55 Proteins for Mus musculus (Mouse)

CD55 Proteins for Cavia porcellus (Guinea pig)

CD55 ELISA Kit

CD55 ELISA Kit for Homo sapiens (Human)