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CD79A

CD79A,即B細(xì)胞抗原受體復(fù)合體α鏈,別名MB-1、IGA、Ig-alpha、IGAB、CD79amolecule。它是一種47kDa的膜糖蛋白,與CD79B結(jié)合形成異二聚體B細(xì)胞受體(BCR),這種受體負(fù)責(zé)B細(xì)胞信號(hào)傳導(dǎo),導(dǎo)致激活、凋亡或過(guò)敏。CD79A的作用機(jī)制主要是與CD79B共同參與B細(xì)胞受體的信號(hào)轉(zhuǎn)導(dǎo)。當(dāng)抗原與BCR結(jié)合后,CD79A/CD79B異二聚體能夠傳遞激活信號(hào),引發(fā)B細(xì)胞的增殖、分化和抗體產(chǎn)生。CD79A的細(xì)胞質(zhì)區(qū)含有免疫受體酪氨酸激活基序(ITAM),是信號(hào)轉(zhuǎn)導(dǎo)的關(guān)鍵結(jié)構(gòu)。CD79A對(duì)B細(xì)胞功能的重要調(diào)控作用,參與B細(xì)胞的抗原識(shí)別、激活、增殖和分化等過(guò)程。CD79A的表達(dá)還與某些B細(xì)胞腫瘤的發(fā)生發(fā)展相關(guān),如B細(xì)胞急性淋巴細(xì)胞性白血病(B-ALL)等。CD79A是B細(xì)胞生物學(xué)研究和B細(xì)胞相關(guān)疾病治療的重要靶點(diǎn)。

熱銷(xiāo)產(chǎn)品

Recombinant Human B-cell antigen receptor complex-associated protein alpha chain (CD79A), partial (Active) (CSB-MP004957HU1)

驗(yàn)證數(shù)據(jù)

CSB-MP004957HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP004957HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CD79A at 2 μg/ml can bind Anti-CD79A recombinant antibody(CSB-RA004957MA1HU). The EC50 is 1.521-1.700 ng/mL.

CD79A Recombinant Monoclonal Antibody (CSB-RA004957MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA004957MA1HU

The Binding Activity of Human CD79A with Anti-CD79A recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD79A(CSB-MP004957HU1) at 2 μg/mL can bind Anti-CD79A recombinant antibody. The EC50 is 1.521-1.700 ng/mL.

CSB-RA004957MA1HU

The Binding Activity of Human CD79A&CD79B with Anti-CD79A recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD79A&CD79B(CSB-MP5861HU) at 2 μg/mL can bind Anti-CD79A recombinant antibody. The EC50 is 8.012-9.339 ng/mL.

CSB-RA004957MA1HU

The purity of CD79A was greater than 95% as determined by SEC-HPLC

CSB-RA004957MA1HU

The Binding Activity of Human CD79A with Anti-CD79A recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD79A(CSB-MP004957HU1p6) at 2 μg/mL can bind Anti-CD79A recombinant antibody. The EC50 is 14.44-16.80 ng/mL.

CSB-RA004957MA1HU

Untransfected HEK-293T cells (green line) and transfected Human CD79A&CD79B HEK-293T stable cells (red line) were stained with anti-CD79A antibody(CSB-RA004957MA1HU) (2μg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-RA004957MA1HU

Untransfected HEK-293T cells (green line) and transfected Human CD79A HEK-293T pool cells (red line) were stained with anti-CD79A antibody(CSB-RA004957MA1HU) (2μg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CD79A Antibodies

CD79A for Homo sapiens (Human)

CD79A Proteins

CD79A Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

CD79A Proteins for Mus musculus (Mouse)

CD79A Proteins for Homo sapiens (Human)

CD79A Proteins for Bos taurus (Bovine)