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CD80

CD80,全稱為Cluster of Differentiation 80,也被稱為B7-1,是一種位于3號染色體的人類基因,屬于免疫球蛋白超家族中的B7蛋白質(zhì)家族。CD80在樹突狀細胞、活化的B細胞、巨噬細胞以及T細胞上表達,與CD86(B7-2)形成共刺激信號,對T細胞活化起到重要作用。CD80在免疫反應中扮演著關鍵角色,與多種疾病如紅斑性狼瘡有關。近年來,針對CD80的藥物研發(fā)取得了顯著進展,如軒竹生物的KM602,作為一種CD80融合蛋白,有望成為治療晚期實體瘤的新選擇。

熱銷產(chǎn)品

Recombinant Human T-lymphocyte activation antigen CD80 (CD80), partial (CSB-MP004959HU1)

驗證數(shù)據(jù)

CSB-MP004959HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CD80 Recombinant Monoclonal Antibody (CSB-RA246383A0HU)

驗證數(shù)據(jù)

CSB-RA246383A0HU

Western Blot
Positive WB detected in: Raji whole cell lysate
All lanes: CD80 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 34, 30, 19 kDa
Observed band size: 60 kDa

CSB-RA246383A0HU

IHC image of CSB-RA246383A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA246383A0HU

Immunoprecipitating CD80 in Raji whole cell lysate
Lane 1: Rabbit control IgG instead of CSB-RA246383A0HU in Raji whole cell lysate. For western blotting,a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-RA246383A0HU(2μg)+ Raji whole cell lysate(500μg)
Lane 3: Raji whole cell lysate (10μg)

CD80 Antibodies

CD80 for Homo sapiens (Human)

CD80 Proteins

CD80 Proteins for Mus musculus (Mouse)

CD80 Proteins for Oryctolagus cuniculus (Rabbit)

CD80 Proteins for Homo sapiens (Human)

CD80 ELISA Kit

CD80 ELISA Kit for Homo sapiens (Human)

CD80 ELISA Kit for Mus musculus (Mouse)