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CDH17

CDH17,即鈣粘蛋白17,別名LI-cadherin。CDH17是一種7D-cadherin家族的成員,其胞外域由EC1-EC7七個(gè)重復(fù)序列構(gòu)成,胞內(nèi)域含18-20個(gè)氨基酸。CDH17的功能是作為多肽轉(zhuǎn)運(yùn)器和細(xì)胞粘附分子來維持上皮組織的完整性。CDH17的粘附機(jī)制與典型cadherin不同,它不需要與α和β-catenins復(fù)合,能在不與其他細(xì)胞質(zhì)成分相互作用的情況下保持粘合功能。CDH17在正常人類細(xì)胞中僅在小腸和結(jié)腸中高表達(dá),而在肝臟、心臟和腎臟等其他組織中不表達(dá)或低表達(dá)。然而,在腫瘤組織中,CDH17在胃、胰腺、肝、食道、膽管癌和結(jié)直腸癌中過表達(dá),其表達(dá)異常與腫瘤的形成和轉(zhuǎn)移密切相關(guān)。CDH17是消化系統(tǒng)惡性腫瘤的潛在診斷標(biāo)志物和治療靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Cadherin-17 (CDH17), partial (Active) (CSB-MP613267HU)

驗(yàn)證數(shù)據(jù)

CSB-MP613267HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP613267HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CDH17 at 2μg/mL can bind Anti-CDH17 recombinant antibody (CSB-RA613267MA1HU), the EC50 is 3.095 to 4.451 ng/mL.

Recombinant Macaca fascicularis Cadherin 17 (CDH17), partial (Active) (CSB-MP4664MOV)

驗(yàn)證數(shù)據(jù)

CSB-MP4664MOV

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP4664MOV

Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CDH17 at 2μg/mL can bind Anti-CDH17 antibody, the EC50 is 4.666-5.447 ng/mL

CDH17 Recombinant Monoclonal Antibody (CSB-RA613267MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA613267MA1HU

The Binding Activity of Human CDH17 with Anti-CDH17 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CDH17 (CSB-MP613267HU) at 2 μg/mL can bind Anti-CDH17 recombinant antibody, the EC50 is 3.095-4.451 ng/mL.

CSB-RA613267MA1HU

Untransfected HEK293T cells surface (green line) and transfected Human CDH17 HEK293T stable cells surface (red line) were stained with anti-CDH17 antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CDH17 Antibodies

CDH17 for Homo sapiens (Human)

CDH17 Proteins

CDH17 Proteins for Rattus norvegicus (Rat)

CDH17 Proteins for Homo sapiens (Human)

CDH17 Proteins for Mus musculus (Mouse)