CDH3

CDH3，即鈣黏蛋白3（Cadherin-3）又稱P-鈣黏蛋白，是鈣黏蛋白家族的重要成員，通過鈣離子依賴的細(xì)胞黏附機(jī)制參與組織形態(tài)發(fā)生和上皮屏障形成。該蛋白在胚胎發(fā)育期廣泛分布于胎盤、皮膚等組織，成年后主要表達(dá)于乳腺、前列腺等腺體基底細(xì)胞層。P-鈣黏蛋白通過與β-catenin等胞內(nèi)蛋白結(jié)合，調(diào)控Wnt信號(hào)通路活性，影響細(xì)胞極性和遷移能力。臨床上，CDH3異常表達(dá)與侵襲性乳腺癌（尤其是三陰性亞型）、胃癌轉(zhuǎn)移密切相關(guān)，其過表達(dá)可能通過破壞細(xì)胞間連接促進(jìn)腫瘤擴(kuò)散。在皮膚病領(lǐng)域，CDH3基因突變已被證實(shí)是先天性厚甲癥4B型的致病原因。目前針對(duì)P-鈣黏蛋白的藥物研發(fā)尚處早期階段，部分研究團(tuán)隊(duì)正在探索單克隆抗體和CAR-T細(xì)胞療法在乳腺癌治療中的應(yīng)用潛力。

熱銷產(chǎn)品

CDH3 Antibody (CSB-PA10715A0Rb)

驗(yàn)證數(shù)據(jù)

Immunohistochemistry analysis of human melanoma using CSB-PA10715A0Rb at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA10715A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

CDH3 Antibody

CDH3 Protein

CDH3 ELISA Kit

CDH3 Antibodies

CDH3 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA005052GA01HU	CDH3 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA10715A0Rb	CDH3 Antibody	Human	ELISA, IHC, IF
CSB-PA006358	CDH3 Antibody	Human	WB, IHC, ELISA
CSB-PA037292	CDH3 Antibody	Human	ELISA,WB
CSB-PA196946	CDH3 Antibody	Human,Mouse	ELISA,WB,IHC

CDH3 Proteins

CDH3 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP005052HU1 CSB-EP005052HU1 CSB-BP005052HU1 CSB-MP005052HU1 CSB-EP005052HU1-B	Recombinant Human Cadherin-3 (CDH3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF005052HU	Recombinant Human Cadherin-3 (CDH3)	in vitro E.coli expression system