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CDK5RAP2

CDK5RAP2 is a protein in humans that is encoded by CDK5RAP2 gene. Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes . In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery. Required for the recruitment of AKAP9 to centrosomes (PubMed. Plays a role in neurogenesis (By similarity).

CDK5RAP2 Antibodies

CDK5RAP2 for Homo sapiens (Human)

CDK5RAP2 Proteins

CDK5RAP2 Proteins for Pan troglodytes (Chimpanzee)

CDK5RAP2 Proteins for Mus musculus (Mouse)

CDK5RAP2 Proteins for Homo sapiens (Human)

CDK5RAP2 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

CDK5RAP2 Proteins for Rattus norvegicus (Rat)