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CDKN1A

CDKN1A,全稱為細(xì)胞周期蛋白依賴性激酶抑制因子1A,也稱為p21或Cip1。它是細(xì)胞周期調(diào)控的關(guān)鍵蛋白,主要作用是抑制細(xì)胞周期進(jìn)程,防止細(xì)胞無限制增殖。CDKN1A蛋白在多種信號(hào)通路中發(fā)揮作用,如p53和Rb通路,參與細(xì)胞生長、分化和凋亡的調(diào)控。與CDKN1A相關(guān)的疾病包括癌癥、衰老相關(guān)疾病等。在藥物研發(fā)方面,針對(duì)CDKN1A的抑制劑正在被研究,以用于癌癥治療。

熱銷產(chǎn)品

Recombinant Human Cyclin-dependent kinase inhibitor 1 (CDKN1A) (CSB-EP005086HUc0)

驗(yàn)證數(shù)據(jù)

CSB-EP005086HUc0

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CDKN1A Antibody (CSB-PA005086DA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA005086DA01HU

IHC image of CSB-PA005086DA01HU diluted at 1:1200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA005086DA01HU

IHC image of CSB-PA005086DA01HU diluted at 1:1200 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA005086DA01HU

Immunofluorescence staining of MCF-7 cells with CSB-PA005086DA01HU at 1:400, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CDKN1A Antibodies

CDKN1A for Homo sapiens (Human)

CDKN1A Proteins

CDKN1A Proteins for Homo sapiens (Human)

CDKN1A Proteins for Mus musculus (Mouse)

CDKN1A Proteins for Felis catus (Cat) (Felis silvestris catus)