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CEL

CEL蛋白全稱為羧酸酯脂酶,又稱膽汁鹽刺激脂酶或CEL相關(guān)蛋白,主要參與脂肪消化代謝過(guò)程。這種酶在胰腺和母乳中高度表達(dá),通過(guò)分解膳食中的膽固醇酯與脂溶性維生素,幫助腸道吸收營(yíng)養(yǎng),尤其對(duì)新生兒生長(zhǎng)發(fā)育至關(guān)重要。其活性異常可能引發(fā)代謝紊亂,與慢性胰腺炎、膽道閉鎖等消化系統(tǒng)疾病密切相關(guān)。研究發(fā)現(xiàn)特定遺傳變異會(huì)導(dǎo)致CEL蛋白截短,進(jìn)而引發(fā)青少年起病的糖尿病合并胰腺萎縮,這類病例被歸類為MODY8型糖尿病。
近年發(fā)現(xiàn)CEL在胰島β細(xì)胞中的異常積累可能加速糖尿病進(jìn)程,這為開(kāi)發(fā)相關(guān)抑制劑提供了方向。針對(duì)CEL缺陷引起的脂肪吸收障礙,已有研究嘗試通過(guò)重組酶替代療法改善患者癥狀,但尚處于動(dòng)物實(shí)驗(yàn)階段。某些天然黃酮類化合物被發(fā)現(xiàn)能調(diào)節(jié)CEL活性,可能成為代謝性疾病干預(yù)的新靶點(diǎn),目前尚未進(jìn)入臨床轉(zhuǎn)化。

熱銷產(chǎn)品

CEL Antibody (CSB-PA325708LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA325708LA01HU

IHC image of CSB-PA325708LA01HU diluted at 1:500 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA325708LA01HU

IHC image of CSB-PA325708LA01HU diluted at 1:500 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CEL Antibodies

CEL for Homo sapiens (Human)

CEL Proteins

CEL Proteins for Homo sapiens (Human)