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CFLAR

CFLAR,全稱為CASP8和FADD樣凋亡調(diào)節(jié)器(CASP8 and FADD-like apoptosis regulator),也被稱為c-FLIP。CFLAR是一種細(xì)胞凋亡調(diào)節(jié)蛋白,主要作用是抑制細(xì)胞凋亡。它通過抑制ASK1的N端二聚化,阻斷ASK1的激活,從而改善并逆轉(zhuǎn)非酒精性脂肪肝炎(NASH)的進(jìn)程。CFLAR在肝臟代謝性疾病中發(fā)揮重要作用,與NASH、脂肪肝等疾病相關(guān)。目前,針對CFLAR的研究正在推進(jìn),有望為NASH等疾病的治療提供新的策略。

熱銷產(chǎn)品

CFLAR Antibody (CSB-PA005282LA01HU)

驗證數(shù)據(jù)

CSB-PA005282LA01HU

Immunofluorescence staining of Hela cells with CSB-PA005282LA01HU at 1:40, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-PA005282LA01HU

Western Blot
Positive WB detected in: Jurkat whole cell lysate, K562 whole cell lysate, 293T whole cell lysate
All lanes: CFLAR antibody at 4µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 56, 26, 42, 28, 52, 51, 40, 31, 35, 53, 34, 24, 50, 45 kDa
Observed band size: 56 kDa

CSB-PA005282LA01HU

IHC image of CSB-PA005282LA01HU diluted at 1:400 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA005282LA01HU

IHC image of CSB-PA005282LA01HU diluted at 1:400 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CFLAR Antibodies

CFLAR for Homo sapiens (Human)

CFLAR Proteins

CFLAR Proteins for Mus musculus (Mouse)

CFLAR Proteins for Homo sapiens (Human)

CFLAR Proteins for Pongo abelii (Sumatran orangutan)