CHRNA1
CHRNA1蛋白全稱煙堿型乙酰膽堿受體α1亞基，俗稱肌肉型nAChR α亞基，是神經(jīng)肌肉接頭處傳遞電信號的核心元件。這種跨膜蛋白形成五聚體離子通道，主導運動神經(jīng)元釋放的乙酰膽堿識別，觸發(fā)骨骼肌收縮反應。CHRNA1功能異常直接導致先天性肌無力綜合征，臨床表現(xiàn)為眼瞼下垂、呼吸肌疲勞等運動障礙，部分突變類型還關聯(lián)夜間發(fā)作性運動障礙。在自身免疫性疾病中，針對該受體的抗體可引發(fā)重癥肌無力危象。
近年來針對CHRNA1的藥物開發(fā)聚焦于變構調(diào)節(jié)技術。新型小分子化合物如GDC-0134通過穩(wěn)定通道開放狀態(tài)，在動物模型中成功逆轉(zhuǎn)獲得性肌無力癥狀。基因療法領域則嘗試利用腺相關病毒載體遞送正常亞基基因，修復遺傳性突變引起的通道功能障礙，目前已完成靈長類動物安全性驗證。值得注意的是，某些蛇毒多肽對該受體具有高選擇性抑制作用，為開發(fā)精準麻醉劑提供了分子模板，但其臨床轉(zhuǎn)化仍受限于免疫原性問題。
熱銷產(chǎn)品
Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1), partial (CSB-BP005386HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CHRNA1 Antibody (CSB-PA11789A0Rb)
驗證數(shù)據(jù)
Western blot
All lanes: CHRNA1 antibody at 2µg/ml + Rat skeletal muscle tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 55, 52 kDa
Observed band size: 55 kDa
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA11789A0Rb at dilution of 1:100
CHRNA1 Antibodies
CHRNA1 for Torpedo californica
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA005386LA01TOT | CHRNA1 Antibody | Torpedo californica | ELISA, WB |
CHRNA1 for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA005386LA01MO | Chrna1 Antibody | Mouse, Human | ELISA, WB |
| CSB-PA005386LB01MO | Chrna1 Antibody, HRP conjugated | Mouse | ELISA |
CHRNA1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA11789A0Rb | CHRNA1 Antibody | Human, Rat | ELISA, WB, IHC |
| CSB-PA11789D0Rb | CHRNA1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA006117 | CHRNA1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA006818 | CHRNA1 Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA169699 | CHRNA1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA587496 | CHRNA1 Antibody | Human,Mouse,Rat | ELISA,IHC |
CHRNA1 Proteins
CHRNA1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP005386MO | Recombinant Mouse Acetylcholine receptor subunit alpha (Chrna1), partial | Yeast |
| CSB-EP005386MO | Recombinant Mouse Acetylcholine receptor subunit alpha (Chrna1), partial | E.coli |
| CSB-EP005386MOa2 | Recombinant Mouse Acetylcholine receptor subunit alpha (Chrna1), partial | E.coli |
CHRNA1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP005386HUe9 | Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1), partial | Yeast |
| CSB-EP005386HU | Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1), partial | E.coli |
| CSB-EP005386HUc2 | Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1), partial | E.coli |
| CSB-BP005386HU | Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1), partial | Baculovirus |
| CSB-BP005386HU | Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1), partial | Baculovirus |
| CSB-EP005386HU-B | Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1), partial, Biotinylated | E.coli |
CHRNA1 Proteins for Tetronarce californica (Pacific electric ray) (Torpedo californica)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP005386TOT | Recombinant Tetronarce californica Acetylcholine receptor subunit alpha (CHRNA1), partial | Yeast |
| CSB-EP005386TOTa2 | Recombinant Tetronarce californica Acetylcholine receptor subunit alpha (CHRNA1), partial | E.coli |
| CSB-BP005386TOT | Recombinant Tetronarce californica Acetylcholine receptor subunit alpha (CHRNA1), partial | Baculovirus |
| CSB-MP005386TOT | Recombinant Tetronarce californica Acetylcholine receptor subunit alpha (CHRNA1), partial | Mammalian cell |
CHRNA1 Proteins for Torpedo californica (Pacific electric ray)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP005386TOT | Recombinant Tetronarce californica Acetylcholine receptor subunit alpha (CHRNA1), partial | E.coli |
| CSB-EP005386TOT-B |
Recombinant Tetronarce californica Acetylcholine receptor subunit alpha (CHRNA1), partial | In Vivo Biotinylation in E.coli |
| CSB-EP005386TOTe1 | Recombinant Tetronarce californica Acetylcholine receptor subunit alpha (CHRNA1), partial | E.coli |
| CSB-EP005386TOTb1 | Recombinant Tetronarce californica Acetylcholine receptor subunit alpha (CHRNA1), partial | E.coli |
