CHRNB1
CHRNB1是神經(jīng)系統(tǒng)中重要的信號(hào)傳導(dǎo)分子，其功能異?？赡芤l(fā)多種疾病。CHRNB1全稱為膽堿能受體煙堿型β1亞基，也被簡稱為nAChR β1或神經(jīng)元乙酰膽堿受體β亞基。它主要分布于神經(jīng)肌肉接頭處，通過與乙酰膽堿結(jié)合觸發(fā)離子通道開放，介導(dǎo)神經(jīng)沖動(dòng)向肌肉的傳遞。若該蛋白發(fā)生突變，可能導(dǎo)致先天性肌無力綜合征，患者表現(xiàn)為肌肉易疲勞、運(yùn)動(dòng)障礙，嚴(yán)重時(shí)可影響呼吸功能。研究還發(fā)現(xiàn)，CHRNB1表達(dá)異?？赡芘c癲癇發(fā)作、自主神經(jīng)功能紊亂存在關(guān)聯(lián)。目前針對(duì)該靶點(diǎn)的藥物開發(fā)集中于小分子調(diào)節(jié)劑，例如某些煙堿類似物已進(jìn)入臨床前研究，旨在通過穩(wěn)定受體構(gòu)象改善神經(jīng)肌肉傳導(dǎo)。此外，傳統(tǒng)藥物如膽堿酯酶抑制劑雖非直接作用于β1亞基，但可通過提升乙酰膽堿濃度間接影響其功能，這類藥物在治療重癥肌無力等疾病中仍發(fā)揮重要作用。
熱銷產(chǎn)品
Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial (CSB-EP005395HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CHRNB1 Antibody (CSB-PA15049A0Rb)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate
All lanes: CHRNB1 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 57, 50 kDa
Observed band size: 57 kDa
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA15049A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA15049A0Rb at dilution of 1:100
Immunofluorescent analysis of PC-3 cells using CSB-PA15049A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CHRNB1 Antibodies
CHRNB1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005395GA01HU | CHRNB1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA437943 | CHRNB1 Antibody | Human | ELISA,WB |
| CSB-PA006822 | CHRNB1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA15049A0Rb | CHRNB1 Antibody | Human | ELISA, WB, IHC, IF |
CHRNB1 Proteins
CHRNB1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP005395HU CSB-MP005395HU CSB-EP005395HU-B |
Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP005395HU | Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial | E.coli |
| CSB-EP005395HUb1 | Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial | E.coli |
| CSB-YP005395HU | Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial | Yeast |
