CRL5
CRL5，別名CUL-5、Vasopressin-activated calcium-mobilizing receptor 1、VACM-1，它是一個(gè)多亞基組成的蛋白復(fù)合物。CRL5來源于細(xì)胞內(nèi)，由骨架蛋白Cullin 5、RING蛋白SAG、銜接蛋白Elongin B/C和底物識(shí)別蛋白SOCS等多個(gè)組分構(gòu)成。其作用機(jī)制主要通過靶向降解一系列關(guān)鍵調(diào)節(jié)蛋白或改變蛋白互相作用方式，參與細(xì)胞因子信號(hào)傳導(dǎo)、炎癥反應(yīng)、病毒感染、腫瘤發(fā)生等生物學(xué)過程。CRL5作為E3泛素連接酶的重要成員，通過精細(xì)調(diào)控蛋白質(zhì)的穩(wěn)定性和活性，維持細(xì)胞內(nèi)環(huán)境的穩(wěn)定，對(duì)生物體的正常生理功能和疾病發(fā)生發(fā)展具有深遠(yuǎn)影響。
熱銷產(chǎn)品
Recombinant Human Cullin-5 (CUL5) (CSB-EP835890HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CUL5 Antibody (CSB-PA835890ESR1HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA835890ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA835890ESR1HU at dilution of 1:100
CRL5 Antibodies
CRL5 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA835890ESR1HU | CUL5 Antibody | Human | ELISA, IHC |
| CSB-PA835890ESR2HU | CUL5 Antibody | Human | ELISA, IHC |
| CSB-PA113726 | CUL5 Antibody | Human,Mouse,Rat | ELISA,IHC |
CRL5 Proteins
CRL5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP835890HU CSB-BP835890HU CSB-MP835890HU CSB-EP835890HU-B |
Recombinant Human Cullin-5 (CUL5) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP835890HU | Recombinant Human Cullin-5 (CUL5) | E.coli |
