CRLF2
CDLF2，即細(xì)胞因子受體樣因子2，別名CRLF2。它是由人類CRLF2基因編碼的I型細(xì)胞因子受體家族成員。CRLF2蛋白是胸腺基質(zhì)淋巴生成素（TSLP）的受體，與白細(xì)胞介素7受體（IL7R）一起，能夠激活STAT3、STAT5和JAK2途徑，這些途徑控制著細(xì)胞增殖和造血系統(tǒng)發(fā)育等過(guò)程。CRLF2的作用機(jī)制涉及與TSLP和IL7R形成功能性復(fù)合體，通過(guò)激活JAK-STAT信號(hào)通路來(lái)刺激細(xì)胞增殖。CRLF2在正常B淋巴細(xì)胞的發(fā)育中起重要作用，但在急性淋巴細(xì)胞白血?。ˋLL）中，CRLF2的過(guò)表達(dá)或重排與疾病的發(fā)生發(fā)展有關(guān)，尤其是在Ph樣ALL（費(fèi)城染色體樣急性淋巴細(xì)胞白血?。┲?，CRLF2的重排導(dǎo)致細(xì)胞表面CRLF2高表達(dá)，刺激前B淋巴細(xì)胞增殖，與不良預(yù)后相關(guān)。
熱銷產(chǎn)品
CRLF2 Antibody (CSB-PA005983ESR1HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA005983ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA005983ESR1HU at dilution of 1:100
CRLF2 Antibodies
CRLF2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA905549 | CRLF2 Antibody | Human | ELISA,IHC |
| CSB-PA976066 | CRLF2 Antibody | Human | ELISA,WB,IHC |
| CSB-PA005983ESR1HU | CRLF2 Antibody | Human | ELISA, IHC |
CRLF2 Proteins
CRLF2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP005983MO CSB-EP005983MO CSB-BP005983MO CSB-MP005983MO CSB-EP005983MO-B |
Recombinant Mouse Cytokine receptor-like factor 2 (Crlf2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CRLF2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP005983RA CSB-EP005983RA CSB-BP005983RA CSB-MP005983RA CSB-EP005983RA-B |
Recombinant Rat Cytokine receptor-like factor 2 (Crlf2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CRLF2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP005983HU CSB-EP005983HU CSB-BP005983HU CSB-MP005983HU CSB-EP005983HU-B |
Recombinant Human Cytokine receptor-like factor 2 (CRLF2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
