CRTAM（CD355）是免疫球蛋白超家族（Ig-SF）的新成員，同時(shí)也是nectin樣蛋白超家族的成員。它作為細(xì)胞表面跨膜蛋白，在免疫系統(tǒng)的形成、應(yīng)答和細(xì)胞交互中扮演重要角色。CRTAM在活化的人NK細(xì)胞、CD8+ T細(xì)胞和CD4+ T細(xì)胞子集上表達(dá)，參與細(xì)胞粘附、極性和增殖，并調(diào)節(jié)淋巴細(xì)胞功能，如促進(jìn)TCD8+細(xì)胞在淋巴結(jié)內(nèi)的粘附和保留。 CRTAM與多種疾病關(guān)聯(lián)，包括炎癥、哮喘、惡性間皮瘤和某些腫瘤疾病。CRTAM能夠影響CD4+ T細(xì)胞的極化，促進(jìn)CD4+ T細(xì)胞的進(jìn)一步分化，并增強(qiáng)細(xì)胞因子的分泌能力。此外，CRTAM在免疫過程中對NK細(xì)胞殺傷腫瘤細(xì)胞起到關(guān)鍵作用，呈現(xiàn)出潛在的腫瘤靶向策略。CRTAM還可以與Necl-2相互作用，在體外促進(jìn)NK細(xì)胞的細(xì)胞毒性和CD8+ T細(xì)胞的IFN-γ分泌，以及在體內(nèi)NK細(xì)胞介導(dǎo)的對表達(dá)Necl-2的腫瘤的排斥反應(yīng)。 CRTAM的表達(dá)受到嚴(yán)格的調(diào)控，主要表達(dá)于激活的免疫細(xì)胞上。在健康人的外周血單個(gè)核細(xì)胞（PBMC）中，CRTAM的表達(dá)量很低，但在哮喘病人的PBMC中高表達(dá)。CRTAM的啟動子與IL-2一樣，受到AP-1轉(zhuǎn)錄因子的調(diào)控。CRTAM激活后會刺激CD8+ T細(xì)胞分泌IFN-γ，并增強(qiáng)CD8+ T細(xì)胞和NK細(xì)胞的殺傷能力。

熱銷產(chǎn)品

● Recombinant Mouse Cytotoxic and regulatory T-cell molecule (Crtam), partial (Active)

驗(yàn)證數(shù)據(jù)

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Cadm1(CSB-MP004425MO) at 2μg/mL can bind Mouse Crtam，the EC₅₀ is 54.36 -61.77 ng/mL.

● Recombinant Human Cytotoxic and regulatory T-cell molecule (CRTAM), partial (Active)

驗(yàn)證數(shù)據(jù)

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CRTAM at 2μg/mL can bind Human CADM1(CSB-MP004425HUd9)，the EC₅₀ is 2.277-2.649 ng/mL.