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CSF3R

CSF3R全稱(chēng)為集落刺激因子3受體,又稱(chēng)粒細(xì)胞集落刺激因子受體(G-CSFR),屬于I型細(xì)胞因子受體超家族。CSF3R由胞外配體結(jié)合區(qū)、跨膜結(jié)構(gòu)域及胞內(nèi)信號(hào)傳導(dǎo)域組成,主要通過(guò)與粒細(xì)胞集落刺激因子(G-CSF)結(jié)合,調(diào)控中性粒細(xì)胞的增殖、分化及存活。在血液系統(tǒng)疾病中,CSF3R基因突變與先天性中性粒細(xì)胞減少癥、慢性中性粒細(xì)胞白血病密切相關(guān),特別是截短型突變可導(dǎo)致受體持續(xù)激活,引發(fā)髓系腫瘤。近年來(lái)研究發(fā)現(xiàn),約30%的慢性中性粒細(xì)胞白血病患者攜帶該基因突變,成為診斷分型的重要標(biāo)志。針對(duì)CSF3R信號(hào)異常,JAK抑制劑魯索替尼已用于攜帶CSF3R-T618I突變患者的臨床治療,而重組G-CSF制劑如培非格司亭則廣泛用于化療后粒細(xì)胞缺乏的挽救治療。目前針對(duì)該靶點(diǎn)的單克隆抗體藥物及小分子激酶抑制劑已進(jìn)入臨床試驗(yàn)階段,為髓系腫瘤精準(zhǔn)治療提供新方向。

熱銷(xiāo)產(chǎn)品

Recombinant Human Granulocyte colony-stimulating factor receptor (CSF3R), partial (CSB-MP860321HUi10)

驗(yàn)證數(shù)據(jù)

CSB-MP860321HUi10

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSF3R Recombinant Monoclonal Antibody (CSB-RA860321MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA860321MA1HU

IHC image of CSB-RA860321MA1HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA860321MA1HU

IHC image of CSB-RA860321MA1HU diluted at 1:100 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSF3R Antibodies

CSF3R for Homo sapiens (Human)

CSF3R Proteins

CSF3R Proteins for Mus musculus (Mouse)

CSF3R Proteins for Homo sapiens (Human)