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CTSL

CTSL,即組織蛋白酶L,別名CatL、Ctsl1,是一種由人類(lèi)基因編碼的溶酶體半胱氨酸蛋白酶,屬于木瓜蛋白酶家族中的成員。CTSL主要在動(dòng)物各種組織細(xì)胞的溶酶體內(nèi)以酶原形式廣泛存在,其相對(duì)分子量約為30000。CTSL的作用機(jī)制涉及其在酸性環(huán)境下的活化,通過(guò)水解多種蛋白質(zhì)底物,包括激素原的激活、體內(nèi)抗原呈遞、組織器官發(fā)育等多個(gè)生理過(guò)程。CTSL在維持動(dòng)物正常生命活動(dòng)中扮演著重要角色,對(duì)于指導(dǎo)蛋白質(zhì)的合成與分解、T細(xì)胞分選等具有重要的生物學(xué)意義。在病理狀態(tài)下,CTSL的異?;罨c腫瘤的浸潤(rùn)和轉(zhuǎn)移、毛囊的形態(tài)發(fā)育及心肌病有關(guān)。CTSL還參與炎癥、血管以及細(xì)胞外基質(zhì)重建過(guò)程,其在腫瘤轉(zhuǎn)移和化療耐藥性中也扮演重要角色。

熱銷(xiāo)產(chǎn)品

CTSL Recombinant Monoclonal Antibody (CSB-RA006193MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA006193MA1HU

IHC image of CSB-RA006193MA1HU diluted at 1:30 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA006193MA1HU

IHC image of CSB-RA006193MA1HU diluted at 1:30 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA006193MA1HU

Immunofluorescence staining of NIH/3T3 cell with CSB-RA006193MA1HU at 1:10, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).

CTSL Antibody (CSB-PA11499A0Rb)

驗(yàn)證數(shù)據(jù)

CSB-PA11499A0Rb

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA11499A0Rb at dilution of 1:100

CSB-PA11499A0Rb

Immunofluorescent analysis of HepG2 cells using CSB-PA11499A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

CTSL Antibodies

CTSL for Chlorocebus aethiops

CTSL for Homo sapiens (Human)

CTSL Proteins

CTSL Proteins for Felis catus (Cat) (Felis silvestris catus)

CTSL Proteins for Bos taurus (Bovine)

CTSL Proteins for Mus musculus (Mouse)

CTSL Proteins for Rattus norvegicus (Rat)

CTSL Proteins for Homo sapiens (Human)

CTSL Proteins for Gallus gallus (Chicken)

CTSL Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

CTSL Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

CTSL Proteins for Ovis aries (Sheep)

CTSL Proteins for Sus scrofa (Pig)

CTSL ELISA Kit

CTSL ELISA Kit for Homo sapiens (Human)

CTSL ELISA Kit for Mus musculus (Mouse)

CTSL ELISA Kit for Rattus norvegicus (Rat)