CXCL4
CXCL4，即C-X-C基序趨化因子配體4，別名PF4、MGC138298、SCYB4、Iroplact和Oncostatin-A。CXCL4是一種由活化血小板的α顆粒釋放的趨化因子，以同源四聚體的形式存在，對肝素有高親和力，并參與血小板聚集。它對中性粒細(xì)胞和單核細(xì)胞具有趨化作用，并且作為造血、血管生成和T細(xì)胞功能的抑制劑。CXCL4在人類肝纖維化中上調(diào)，并在實(shí)驗(yàn)性肝纖維化中通過介導(dǎo)星狀細(xì)胞增殖、遷移和肝內(nèi)免疫細(xì)胞招募發(fā)揮非冗余的功能性作用。此外，CXCL4還在動(dòng)脈粥樣硬化病變的早期和晚期均有表達(dá)，并已證實(shí)其表達(dá)與臨床癥狀的嚴(yán)重程度成正比。在CXCL4缺乏小鼠模型中，動(dòng)脈粥樣硬化病變較小且巨噬細(xì)胞浸潤較少。這些功能使得CXCL4在多種疾病的發(fā)生發(fā)展中扮演著重要角色，特別是在炎癥反應(yīng)和腫瘤進(jìn)展中。
熱銷產(chǎn)品
PF4 Antibody (CSB-PA017809LA01HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-PA017809LA01HU diluted at 1:200 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Human Platelet Factor 4,PF-4 ELISA Kit (CSB-E07882h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E07882h
規(guī)格：96T/48T
靈敏度：1.56 ng/mL
檢測范圍：6.25 ng/mL-400 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CXCL4 Antibodies
CXCL4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA958757 | PF4 Antibody | Human,Rat | IHC,ELISA |
| CSB-PA017809LA01HU | PF4 Antibody | Human | ELISA, IHC |
| CSB-PA017809LB01HU | PF4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA017809LC01HU | PF4 Antibody, FITC conjugated | Human | |
| CSB-PA017809LD01HU | PF4 Antibody, Biotin conjugated | Human | ELISA |
CXCL4 Proteins
CXCL4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP017809HU CSB-BP017809HU CSB-MP017809HU CSB-EP017809HU-B |
Recombinant Human Platelet factor 4 (PF4) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP000661HU | Recombinant Human Platelet factor 4 protein (PF4) | E.Coli |
CXCL4 ELISA Kit
CXCL4 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E07882h | Human Platelet Factor 4,PF-4 ELISA Kit | serum, plasma, tissue homogenates | 1.56 ng/mL |
