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DDIT3

DDIT3,即DNA損傷誘導(dǎo)轉(zhuǎn)錄本3,別名CHOP、GADD153,是一種轉(zhuǎn)錄因子,對(duì)細(xì)胞應(yīng)激反應(yīng)尤其是內(nèi)質(zhì)網(wǎng)應(yīng)激具有關(guān)鍵調(diào)控作用。它通過(guò)與ATF4相互作用,促進(jìn)自噬相關(guān)基因表達(dá),并通過(guò)抑制mTOR信號(hào)通路激活細(xì)胞自噬。DDIT3還參與凋亡過(guò)程,通過(guò)調(diào)節(jié)Bcl-2家族和C/EBPδ誘導(dǎo)線(xiàn)粒體相關(guān)凋亡。DDIT3在腫瘤細(xì)胞自噬與凋亡調(diào)控中扮演重要角色,其異常表達(dá)可能增加腫瘤細(xì)胞對(duì)治療的敏感性,是腫瘤治療的潛在靶點(diǎn)。在谷氨酰胺饑餓條件下,DDIT3通過(guò)雙重機(jī)制平衡糖酵解和線(xiàn)粒體氧化磷酸化,減少活性氧產(chǎn)生,幫助腫瘤細(xì)胞適應(yīng)代謝壓力,顯示其在腫瘤細(xì)胞代謝調(diào)控中的生物學(xué)意義。

熱銷(xiāo)產(chǎn)品

DDIT3 Recombinant Monoclonal Antibody (CSB-RA918842A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA918842A0HU

Overlay Peak curve showing Hela cells stained with CSB-RA918842A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

DDIT3 Antibodies

DDIT3 for Homo sapiens (Human)

DDIT3 Proteins

DDIT3 Proteins for Homo sapiens (Human)

DDIT3 Proteins for Mus musculus (Mouse)

DDIT3 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

DDIT3 Proteins for Bos taurus (Bovine)

DDIT3 Proteins for Rattus norvegicus (Rat)