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DERL2

Derlin-2 is a protein in humans that is encoded by DERL2 gene. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins.

DERL2 Proteins

DERL2 Proteins for Dictyostelium discoideum (Slime mold)

DERL2 Proteins for Pongo abelii (Sumatran orangutan)

DERL2 Proteins for Mus musculus (Mouse)

DERL2 Proteins for Homo sapiens (Human)