DNMT3B
DNMT3B，即DNA甲基轉(zhuǎn)移酶3β，別名ICF、ICF1。DNMT3B是一種DNA甲基轉(zhuǎn)移酶，主要在胚胎發(fā)育早期表達(dá)和活躍，負(fù)責(zé)從頭甲基化，即在DNA序列中添加甲基基團(tuán)到胞嘧啶的第五碳原子上。DNMT3B將甲基從S-腺苷甲硫氨酸（SAM）轉(zhuǎn)移到胞嘧啶上，這一過(guò)程對(duì)基因表達(dá)調(diào)控、胚胎發(fā)育、細(xì)胞分化、基因印記、轉(zhuǎn)座子沉默和X染色體失活等生理過(guò)程至關(guān)重要。DNMT3B在維持DNA甲基化模式、基因表達(dá)調(diào)控和染色質(zhì)結(jié)構(gòu)中發(fā)揮重要作用。DNMT3B的異常表達(dá)或功能失調(diào)與多種疾病相關(guān)，包括免疫缺陷、中心粒不穩(wěn)定和面部異常綜合征（ICF綜合征）以及腫瘤的發(fā)生發(fā)展。
熱銷(xiāo)產(chǎn)品
DNMT3B Antibody (CSB-PA883358HA01HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: DNMT3B antibody at 14µg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 96, 94, 87, 81, 89, 95, 78, 82 kDa
Observed band size: 96, 37 kDa
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA883358HA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA883358HA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA883358HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
DNMT3B Antibodies
DNMT3B for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA593881 | DNMT3B Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA002178 | DNMT3B Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA883358HA01HU | DNMT3B Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA883358HB01HU | DNMT3B Antibody, HRP conjugated | Human | ELISA |
| CSB-PA883358HC01HU | DNMT3B Antibody, FITC conjugated | Human | |
| CSB-PA883358HD01HU | DNMT3B Antibody, Biotin conjugated | Human | ELISA |
DNMT3B Proteins
DNMT3B Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP883358HU CSB-EP883358HU CSB-BP883358HU CSB-MP883358HU CSB-EP883358HU-B |
Recombinant Human DNA (cytosine-5)-methyltransferase 3B (DNMT3B), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
