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DPYSL2

DPYSL2,全稱為Dihydropyrimidinase-related protein 2,常見別名包括DRP-2、CRMP-2等。該蛋白在神經(jīng)元發(fā)育、極性、軸突生長(zhǎng)、引導(dǎo)、生長(zhǎng)錐塌陷和細(xì)胞遷移中發(fā)揮著至關(guān)重要的作用,與3類信號(hào)蛋白和鈣通道相互作用,參與神經(jīng)元生長(zhǎng)和突觸可塑性的調(diào)控。DPYSL2蛋白的異常表達(dá)或功能異常與多種神經(jīng)系統(tǒng)疾病相關(guān),如阿爾茨海默病、帕金森病等。目前,針對(duì)DPYSL2蛋白的藥物研發(fā)尚處于早期階段,但已有研究表明,靶向DPYSL2蛋白的藥物可能為治療阿爾茨海默病等神經(jīng)系統(tǒng)疾病提供新的治療策略。

熱銷產(chǎn)品

Recombinant Human Dihydropyrimidinase-related protein 2 (DPYSL2) (CSB-YP614975HU)

驗(yàn)證數(shù)據(jù)

CSB-YP614975HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-YP614975HU

Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP614975HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) DPYSL2.

CSB-YP614975HU

Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP614975HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) DPYSL2.

DPYSL2 Recombinant Monoclonal Antibody (CSB-RA029079A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA029079A0HU

IHC image of CSB-RA029079A0HU diluted at 1:50 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.35% DAB.

CSB-RA029079A0HU

Immunofluorescence staining of SH-SY5Y with CSB-RA029079A0HU at 1:25, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 506-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA029079A0HU

Overlay Peak curve showing SH-SY5Y cells stained with CSB-RA029079A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

DPYSL2 Antibodies

DPYSL2 for Homo sapiens (Human)

DPYSL2 Proteins

DPYSL2 Proteins for Homo sapiens (Human)