EFNB2

EFNB2蛋白全稱為Ephrin-B2，也被稱為LERK5或HTKL，屬于ephrin蛋白家族成員。這類蛋白通常以膜結(jié)合形式存在，通過與相鄰細(xì)胞表面的Eph受體相互作用，雙向調(diào)節(jié)細(xì)胞黏附、遷移及組織邊界形成。EFNB2在胚胎發(fā)育階段對(duì)血管網(wǎng)絡(luò)構(gòu)建及神經(jīng)纖維導(dǎo)向具有關(guān)鍵作用，成年后參與組織修復(fù)與炎癥反應(yīng)調(diào)控。EFNB2異常表達(dá)與多種實(shí)體瘤的侵襲轉(zhuǎn)移密切相關(guān)，尤其在乳腺癌、膠質(zhì)瘤中可能通過促進(jìn)新生血管生成加速病情進(jìn)展。心血管領(lǐng)域研究則提示，EFNB2在動(dòng)脈粥樣硬化斑塊的不穩(wěn)定性和心肌缺血后血管再生過程中扮演雙重角色。近年來，針對(duì)該蛋白的靶向藥物開發(fā)聚焦于抑制其介導(dǎo)的病理過程，已有數(shù)款單抗類藥物進(jìn)入臨床前研究階段，其中部分藥物在動(dòng)物模型中顯示出阻斷腫瘤轉(zhuǎn)移的潛力。此外，基于EFNB2結(jié)構(gòu)的生物材料也被探索用于引導(dǎo)神經(jīng)再生等再生醫(yī)學(xué)領(lǐng)域。

熱銷產(chǎn)品

EFNB2 Antibody (CSB-PA007466ESR2HU)

驗(yàn)證數(shù)據(jù)

Western blot
All lanes: EFNB2 antibody at 6μg/ml + Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 37 kDa
Observed band size: 37 kDa

Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA007466ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA007466ESR2HU at dilution of 1:100

EFNB2 Antibody

EFNB2 Protein

EFNB2 ELISA Kit

EFNB2 Antibodies

EFNB2 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA007466ESR1HU	EFNB2 Antibody	Human	ELISA, IHC
CSB-PA587215	EFNB2 (Ab-316) Antibody	Human,Mouse	ELISA,WB
CSB-PA077593	EFNB2 (Ab-330) Antibody	Human,Mouse	ELISA,WB,IF
CSB-PA166153	Phospho-EFNB2 (Tyr316) Antibody	Human,Mouse	ELISA,WB
CSB-PA216331	Phospho-EFNB2 (Tyr330) Antibody	Human,Mouse	ELISA,WB
CSB-PA007466ESR2HU	EFNB2 Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA035369	EFNB2 Antibody	Human,Mouse	ELISA,IHC

EFNB2 Proteins

EFNB2 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP007466HU1 CSB-EP007466HU1 CSB-BP007466HU1 CSB-MP007466HU1 CSB-EP007466HU1-B	Recombinant Human Ephrin-B2 (EFNB2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF007466HU	Recombinant Human Ephrin-B2 (EFNB2)	in vitro E.coli expression system