ENPP1
ENPP1，即外核苷酸焦磷酸酶/磷酸二酯酶1，別名PC-1、CD203c等。它是一種細(xì)胞外糖蛋白，由人體細(xì)胞自身的基因編碼，主要在免疫系統(tǒng)、骨代謝和能量代謝中發(fā)揮作用。ENPP1的作用機(jī)制包括水解細(xì)胞外的核苷酸三磷酸產(chǎn)生焦磷酸鹽，這一過(guò)程在骨礦化和胰島素信號(hào)傳導(dǎo)中具有重要作用。此外，ENPP1還能通過(guò)水解免疫遞質(zhì)2'3'-環(huán)GMP-AMP（cGAMP）來(lái)抑制STING信號(hào)通路，從而調(diào)節(jié)先天免疫反應(yīng) 。ENPP1在生物學(xué)上的意義非常廣泛，它參與多種生理和病理過(guò)程，包括骨礦化、胰島素信號(hào)傳導(dǎo)、腫瘤免疫逃逸等。ENPP1的表達(dá)與多種疾病相關(guān)，例如在腫瘤微環(huán)境中，ENPP1的高表達(dá)與不良預(yù)后相關(guān)，其水解cGAMP活性可能抑制了cGAS-STING通路，從而抑制了抗腫瘤免疫反應(yīng) 。此外，ENPP1還可能參與調(diào)節(jié)細(xì)胞外ATP/腺苷平衡，影響腫瘤微環(huán)境中的免疫細(xì)胞浸潤(rùn)和功能 。因此，ENPP1是免疫生物學(xué)研究和癌癥治療中的一個(gè)潛在靶點(diǎn)。
熱銷(xiāo)產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ENPP1 Antibody (CSB-PA007679LA01HU)
驗(yàn)證數(shù)據(jù)
Immunofluorescent analysis of HepG2 cells using CSB-PA007679LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL007679MO
規(guī)格：96T/48T
靈敏度：0.078 ng/mL
檢測(cè)范圍：0.312 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
ENPP1 Proteins
ENPP1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-BP007679MO CSB-MP007679MO CSB-EP007679MO-B |
Recombinant Mouse Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Enpp1), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP007679MO | Recombinant Mouse Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Enpp1), partial | E.coli |
| CSB-YP007679MO | Recombinant Mouse Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Enpp1), partial | Yeast |
ENPP1 ELISA Kit
ENPP1 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL007679MO | Mouse Ectonucleotide pyrophosphatase/phosphodiesterase family member 1(ENPP1) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
