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EPOR

EPOR,即紅細(xì)胞生成素受體,別名EPO受體、CD235。它是一種由EPOR基因編碼的細(xì)胞表面受體,主要在紅系祖細(xì)胞上表達(dá)。EPOR的作用機(jī)制涉及與其配體紅細(xì)胞生成素(EPO)結(jié)合,激活JAK2/STAT5、MAPK等信號通路,促進(jìn)紅細(xì)胞的生成和成熟。EPOR的功能異常與某些遺傳性貧血疾病有關(guān),如家族性紅細(xì)胞生成不良。此外,EPOR激動劑在臨床上用于治療某些類型的貧血,如慢性腎病相關(guān)的貧血。EPOR也是運(yùn)動生理學(xué)和高海拔適應(yīng)研究中的一個重要分子。

熱銷產(chǎn)品

Recombinant Human Erythropoietin receptor (EPOR), partial (CSB-MP007744HU1)

驗(yàn)證數(shù)據(jù)

CSB-MP007744HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

EPOR Antibody (CSB-PA007744LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA007744LA01HU

Western Blot
Positive WB detected in: 293T whole cell lysate, Hela whole cell lysate
All lanes: EPOR antibody at 4.3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 56, 27, 36 kDa
Observed band size: 56 kDa

CSB-PA007744LA01HU

IHC image of CSB-PA007744LA01HU diluted at 1:400 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA007744LA01HU

Immunofluorescence staining of Hela cells with CSB-PA007744LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

EPOR Antibodies

EPOR for Homo sapiens (Human)

EPOR Proteins

EPOR Proteins for Mus musculus (Mouse)

EPOR Proteins for Homo sapiens (Human)

EPOR Proteins for Xenopus laevis (African clawed frog)

EPOR Proteins for Sus scrofa (Pig)

EPOR Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

EPOR Proteins for Canis lupus familiaris (Dog)(Canis familiaris)

EPOR Proteins for Rattus norvegicus (Rat)

EPOR ELISA Kit

EPOR ELISA Kit for Homo sapiens (Human)