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EPRS1

EPRS1,全名為谷氨酰-脯氨酰-tRNA合成酶1,也被稱為EARS、EPRS、PARS、QARS、QPRS等。該蛋白在蛋白質(zhì)合成過(guò)程中扮演重要角色,能夠?qū)⒐劝彼岷透彼徇B接到相應(yīng)的tRNA上。近期研究發(fā)現(xiàn),EPRS1在腎小管間質(zhì)炎中發(fā)揮關(guān)鍵作用,其表達(dá)水平與腎臟炎癥和纖維化程度密切相關(guān)。針對(duì)EPRS1的靶向抑制劑在治療腎小管間質(zhì)炎方面展現(xiàn)出潛力,有望成為未來(lái)治療腎臟疾病的新選擇。此外,EPRS1在肥胖和代謝性疾病的研究中也備受關(guān)注,其作為藥物研發(fā)的新靶點(diǎn),為相關(guān)疾病的治療提供了新的思路。

熱銷產(chǎn)品

EPRS Antibody (CSB-PA007747LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA007747LA01HU

Western Blot
Positive WB detected in: 293T whole cell lysate
All lanes: EPRS antibody at 7.4μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 171 kDa
Observed band size: 171 kDa

CSB-PA007747LA01HU

IHC image of CSB-PA007747LA01HU diluted at 1:600 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA007747LA01HU

Immunofluorescence staining of Hela cells with CSB-PA007747LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

EPRS1 Antibodies

EPRS1 for Homo sapiens (Human)

EPRS1 Proteins

EPRS1 Proteins for Homo sapiens (Human)