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EXOSC10

EXOSC10,即外泌體組分10,別名RRP6、PMSCL、Rrp6p、PM-Scl、PMSCL2、PM/Scl-100等。它是一種核糖核酸外切酶,參與RNA的代謝過程,包括5.8S rRNA的成熟和通過端粒酶對端粒維持的負調(diào)節(jié)。EXOSC10在胞質(zhì)溶膠、核腔和轉(zhuǎn)錄活性染色質(zhì)中都有分布,是核外泌體(RNase復合物)的一部分。其作用機制涉及啟用3'-5'-核糖核酸外切酶活性,通過降解特定RNA分子來調(diào)控基因表達。EXOSC10對維持基因表達的穩(wěn)定性和參與細胞周期調(diào)控具有重要作用,其異常表達與多種疾病相關,包括肝病、癌癥和神經(jīng)系統(tǒng)疾病等。

熱銷產(chǎn)品

EXOSC10 Antibody (CSB-PA007889LA01HU)

驗證數(shù)據(jù)

CSB-PA007889LA01HU

IHC image of CSB-PA007889LA01HU diluted at 1:300 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

EXOSC10 Antibodies

EXOSC10 for Homo sapiens (Human)