FABP4

FABP4，全稱為脂肪酸結(jié)合蛋白4，也被稱為脂肪細(xì)胞脂肪酸結(jié)合蛋白（aP2）、422/aP2、AFABP、ALBP、ALBP/Ap2、Ap2、Lbpl、P15等，是一種主要在脂肪細(xì)胞中表達(dá)的脂質(zhì)轉(zhuǎn)運蛋白。它負(fù)責(zé)將長鏈脂肪酸和視黃酸轉(zhuǎn)運至細(xì)胞核內(nèi)各自的受體，在脂質(zhì)和視黃酸轉(zhuǎn)運中發(fā)揮著關(guān)鍵作用。FABP4與其他細(xì)胞因子、炎癥介質(zhì)、腫瘤組織等共同構(gòu)成腫瘤微環(huán)境，通過激活核因子κB和c-Jun n-末端激酶途徑調(diào)節(jié)炎性反應(yīng)，并促進(jìn)脂肪分解和抑制脂肪生成。此外，F(xiàn)ABP4還介導(dǎo)腫瘤相關(guān)巨噬細(xì)胞和脂肪細(xì)胞的代謝和炎癥反應(yīng)，進(jìn)而影響腫瘤的進(jìn)展。
FABP4與肥胖、代謝疾病和心臟疾病密切相關(guān)。在肥胖人群中，F(xiàn)ABP4的水平較高，與肥胖、代謝疾病和心臟疾病的發(fā)生發(fā)展有關(guān)。研究表明，F(xiàn)ABP4可能成為肥胖相關(guān)乳腺癌診療的新方向，其在乳腺癌早期診療、預(yù)測預(yù)后及治療等方面具有應(yīng)用前景。目前，已有多種靶向FABP4的抑制劑，如小分子抑制劑和si-RNA等，但尚無抑制劑應(yīng)用于臨床。未來，加大對FABP4的相關(guān)研究及藥物開發(fā)和相關(guān)臨床試驗，將為治療癌癥患者提供新的選擇，改善患者的預(yù)后。

熱銷產(chǎn)品

Recombinant Human Fatty acid-binding protein, adipocyte (FABP4) (CSB-EP007945HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

FABP4 Antibody (CSB-PA007945LA01HU)

驗證數(shù)據(jù)

Western Blot
Positive WB detected in: 293T whole cell lysate, U251 whole cell lysate, PC-3 whole cell lysate, Hela whole cell lysate, U87 whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate
All lanes: FABP4 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 15 kDa
Observed band size: 15 kDa

IHC image of CSB-PA007945LA01HU diluted at 1:100 and staining in paraffin-embedded human glioma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG labeled by HRP and visualized using 0.05% DAB.

FABP4 Antibody

FABP4 Protein

FABP4 ELISA Kit

FABP4 Antibodies

FABP4 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA007945GA01HU	FABP4 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA114281	FABP4 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-RA007945A0HU	FABP4 Recombinant Monoclonal Antibody	Human	ELISA
CSB-PA007945LA01HU	FABP4 Antibody	Human	ELISA, WB, IHC
CSB-PA007945LB01HU	FABP4 Antibody, HRP conjugated	Human	ELISA
CSB-PA007945LC01HU	FABP4 Antibody，F(xiàn)ITC conjugated	Human
CSB-PA007945LD01HU	FABP4 Antibody，Biotin conjugated	Human	ELISA

FABP4 Proteins

FABP4 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP007945RA CSB-EP007945RA CSB-BP007945RA CSB-MP007945RA CSB-EP007945RA-B	Recombinant Rat Fatty acid-binding protein, adipocyte (Fabp4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FABP4 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP007945HU CSB-BP007945HU CSB-MP007945HU CSB-EP007945HU-B	Recombinant Human Fatty acid-binding protein, adipocyte (FABP4)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP007945HU	Recombinant Human Fatty acid-binding protein, adipocyte (FABP4)	E.coli

FABP4 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP007945BO CSB-EP007945BO CSB-BP007945BO CSB-MP007945BO CSB-EP007945BO-B	Recombinant Bovine Fatty acid-binding protein, adipocyte (FABP4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FABP4 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-BP007945MO CSB-EP007945MO-B	Recombinant Mouse Fatty acid-binding protein, adipocyte (Fabp4)	Baculovirus In Vivo Biotinylation in E.coli

FABP4 Proteins for Sus scrofa (Pig)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP007945PI CSB-EP007945PI CSB-BP007945PI CSB-MP007945PI CSB-EP007945PI-B	Recombinant Pig Fatty acid-binding protein, adipocyte (FABP4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FABP4 Proteins for Cervus elaphus (Red deer)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP413810DRN CSB-EP413810DRN CSB-BP413810DRN CSB-MP413810DRN CSB-EP413810DRN-B	Recombinant Cervus elaphus Fatty acid-binding protein, adipocyte (FABP4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FABP4 Proteins for Spermophilus tridecemlineatus (Thirteen-lined ground squirrel) (Ictidomys tridecemlineatus)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP857516FKA CSB-EP857516FKA CSB-BP857516FKA CSB-MP857516FKA CSB-EP857516FKA-B	Recombinant Spermophilus tridecemlineatus Fatty acid-binding protein, adipocyte (FABP4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli