FBXO3
FBXO3，別名FBA、FBX3。FBXO3由人類FBXO3基因編碼，該基因位于染色體11p13位置。FBXO3是F-box蛋白家族的成員，其特征是含有約40個(gè)氨基酸的F-box基序。F-box蛋白是SCF（SKP1-Cullin-F-box）泛素蛋白連接酶復(fù)合體的四個(gè)亞基之一，參與磷酸化依賴性泛素化過(guò)程。FBXO3屬于Fbxs類，包含不同的蛋白質(zhì)-蛋白質(zhì)相互作用模塊或無(wú)可識(shí)別基序。FBXO3具有多種生物學(xué)功能，包括調(diào)節(jié)免疫病理、神經(jīng)性疾病和抗病毒反應(yīng)。FBXO3在炎癥性疾病和人類惡性腫瘤中的作用尤為重要，包括類風(fēng)濕性關(guān)節(jié)炎、白血病、垂體腺瘤和口腔鱗狀細(xì)胞癌。FBXO3通過(guò)泛素化和降解特定底物來(lái)調(diào)節(jié)多種細(xì)胞功能，成為治療包括癌癥在內(nèi)的多種疾病的新靶點(diǎn)。
熱銷(xiāo)產(chǎn)品
Recombinant Human F-box only protein 3 (FBXO3) (CSB-YP892132HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
FBXO3 Antibody (CSB-PA892132LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA892132LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA892132LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Western Blot
Positive WB detected in: Mouse kidney tissue
All lanes: FBXO3 antibody at 4μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 55, 48, 47 kDa
Observed band size: 55 kDa
FBXO3 Antibodies
FBXO3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA008495GA01HU | FBXO3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA892132LA01HU | FBXO3 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA892132LB01HU | FBXO3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA892132LC01HU | FBXO3 Antibody, FITC conjugated | Human | |
| CSB-PA892132LD01HU | FBXO3 Antibody, Biotin conjugated | Human | ELISA |
FBXO3 Proteins
FBXO3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP892132HU | Recombinant Human F-box only protein 3 (FBXO3) | Yeast |
| CSB-EP892132HU CSB-BP892132HU CSB-MP892132HU CSB-EP892132HU-B |
Recombinant Human F-box only protein 3 (FBXO3) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
