FCGR3A，即Fc片段的IgG受體IIIa，別名CD16a。它是一種低親和力的IgG Fc區(qū)受體，屬于免疫球蛋白超家族成員，主要表達在自然殺傷(NK)細胞、巨噬細胞、肥大細胞和中性粒細胞等免疫效應(yīng)細胞表面。FCGR3A通過與IgG1和IgG3的Fc段結(jié)合，誘導免疫效應(yīng)細胞的細胞毒作用，即抗體依賴的細胞介導的細胞毒作用(ADCC)，殺傷靶細胞，也可促進IFN-γ、TNF和基質(zhì)金屬蛋白酶等細胞因子的分泌，影響細胞免疫功能發(fā)揮。FCGR3A在生物學上的意義主要體現(xiàn)在其參與的多種免疫反應(yīng)中。它不僅在NK細胞介導的ADCC中發(fā)揮作用，還是單克隆抗體介導的分子靶向治療的重要結(jié)合位點，尤其在惡性腫瘤治療中應(yīng)用廣泛。此外，F(xiàn)CGR3A的基因多態(tài)性與某些癌癥的治療反應(yīng)相關(guān)，其表達水平可能與腫瘤的預(yù)后相關(guān)，有助于作為預(yù)后生物標志物。FCGR3A的表達還與免疫檢查點分子以及腫瘤相關(guān)巨噬細胞(TAM)基因標志物呈正相關(guān)，表明其在腫瘤免疫微環(huán)境中可能發(fā)揮重要作用。

熱銷產(chǎn)品

Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A), partial (CSB-EP008543HU2)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

FCGR3A Recombinant Monoclonal Antibody (CSB-RA008543MA1HU)

驗證數(shù)據(jù)

Immunofluorescence staining of Hela cell with CSB-RA008543MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).