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FGFR1

FGFR1,即成纖維細胞生長因子受體1,它是一種膜結(jié)合蛋白,由FGFR1基因編碼。FGFR1廣泛存在于多種組織中,是成纖維細胞生長因子(FGF)家族的高親和力受體。其作用機制是FGF與其結(jié)合后,F(xiàn)GFR1發(fā)生二聚化或寡聚化,激活其內(nèi)在的酪氨酸激酶活性,進而觸發(fā)下游的信號傳導途徑,如RAS/MAPK、PI3K/AKT等。這些信號通路參與調(diào)節(jié)細胞的增殖、分化、遷移和存活。FGFR1的生物學意義在于其在胚胎發(fā)育、組織修復、血管生成和腫瘤發(fā)生等過程中的重要作用。FGFR1的異常激活與多種癌癥的發(fā)生發(fā)展密切相關(guān),因此,F(xiàn)GFR1也是腫瘤治療的潛在靶點。

熱銷產(chǎn)品

Recombinant Human Fibroblast growth factor receptor 1 (FGFR1), partial (CSB-YP008642HU)

驗證數(shù)據(jù)

CSB-YP008642HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

FGFR1 Recombinant Monoclonal Antibody (CSB-RA008642MA1HU)

驗證數(shù)據(jù)

CSB-RA008642MA1HU

IHC image of CSB-RA008642MA1HU diluted at 1:100 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Rabbit IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA008642MA1HU

Immunofluorescence staining of Hela cell with CSB-RA008642MA1HU at 1:20, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA008642MA1HU

Overlay Peak curve showing MCF7 cells stained with CSB-RA008642MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Rabbit IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was rabbit IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,026 events was performed.

FGFR1 Antibodies

FGFR1 for Homo sapiens (Human)

FGFR1 Proteins

FGFR1 Proteins for Rattus norvegicus (Rat)

FGFR1 Proteins for Homo sapiens (Human)

FGFR1 Proteins for Gallus gallus (Chicken)

FGFR1 Proteins for Mus musculus (Mouse)

FGFR1 Proteins for Xenopus laevis (African clawed frog)

FGFR1 Proteins for Pleurodeles waltl (Iberian ribbed newt)

FGFR1 Proteins for Dugesia japonica (Planarian)