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FNDC5

FNDC5,全稱為纖維連接蛋白III型結(jié)構(gòu)域包含蛋白5,是一種在骨骼肌中高表達的蛋白。它編碼的鳶尾素是一種運動誘導激素,能夠促進白色脂肪組織褐變,幫助身體消耗能量,維持能量平衡。鳶尾素還能與成纖維細胞生長因子21(FGF21)協(xié)同作用,共同調(diào)節(jié)脂肪組織的代謝,改善肥胖等代謝性疾病。研究表明,F(xiàn)NDC5基因的變異可能會影響鳶尾素的結(jié)構(gòu)和功能,增加肥胖及相關(guān)疾病的發(fā)生風險。目前,針對FNDC5蛋白的藥物研發(fā)尚處于早期階段,但已有研究顯示,F(xiàn)NDC5蛋白有望成為治療肥胖及相關(guān)代謝性疾病的潛在靶點。

熱銷產(chǎn)品

Recombinant Human Fibronectin type III domain-containing protein 5 (FNDC5), partial (CSB-EP836707HU)

驗證數(shù)據(jù)

CSB-EP836707HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

FNDC5 Antibody (CSB-PA836707OA01HU)

驗證數(shù)據(jù)

CSB-PA836707OA01HU

IHC image of CSB-PA836707OA01HU diluted at 1:200 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-PA836707OA01HU

IHC image of CSB-PA836707OA01HU diluted at 1:200 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-PA836707OA01HU

Immunofluorescence staining of SH-SY5Y cells with CSB-PA836707OA01HU-IF at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human Fibronectin type III domain-containing protein 5(FNDC5) ELISA kit (CSB-EL008770HU)

驗證數(shù)據(jù)

CSB-EL008770HU 標準曲線

貨號:CSB-EL008770HU

規(guī)格:96T/48T

靈敏度:1.95 ng/mL

檢測范圍:7.8 ng/mL-500 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

FNDC5 Antibodies

FNDC5 for Homo sapiens (Human)

FNDC5 Proteins

FNDC5 Proteins for Homo sapiens (Human)

FNDC5 ELISA Kit

FNDC5 ELISA Kit for Homo sapiens (Human)