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FOXO3

FOXO3,全稱為叉頭框轉(zhuǎn)錄因子3,是叉頭框O類轉(zhuǎn)錄因子家族的重要成員。該蛋白參與多種生物學(xué)過(guò)程,包括能量代謝、細(xì)胞凋亡、DNA修復(fù)和氧化應(yīng)激等。FOXO3蛋白在維持細(xì)胞穩(wěn)態(tài)和組織健康中發(fā)揮著關(guān)鍵作用。研究表明,F(xiàn)OXO3蛋白在皮膚健康中具有重要作用,其表達(dá)與黑素生成、傷口愈合、痤瘡和黑色素瘤等皮膚相關(guān)問(wèn)題密切相關(guān)。此外,F(xiàn)OXO3蛋白還與AML(急性髓系白血病)的發(fā)生發(fā)展及耐藥性密切相關(guān)。研究發(fā)現(xiàn),F(xiàn)OXO3蛋白的高表達(dá)與AML患者的不良預(yù)后相關(guān),并且可能通過(guò)調(diào)節(jié)自噬參與AML蒽環(huán)類藥物耐藥的機(jī)制?;谶@些發(fā)現(xiàn),F(xiàn)OXO3蛋白有望成為AML治療中的潛在靶點(diǎn)。目前,針對(duì)FOXO3蛋白的藥物研發(fā)正在積極開(kāi)展中,以期開(kāi)發(fā)出更有效的AML治療藥物。

熱銷產(chǎn)品

Recombinant Human Forkhead box protein O3 (FOXO3), partial (CSB-EP008836HU1)

驗(yàn)證數(shù)據(jù)

CSB-EP008836HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

FOXO3 Recombinant Monoclonal Antibody (CSB-RA008836A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA008836A0HU

Western Blot
Positive WB detected in: 293 whole cell lysate, Jurkat whole cell lysate, SH-SY5Y whole cell lysate, U87 whole cell lysate
All lanes: FOXO3A antibody at 1.8μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 72, 49 KDa
Observed band size: 72-90 KDa

CSB-RA008836A0HU

IHC image of CSB-RA008836A0HU diluted at 1:180 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-RA008836A0HU

IHC image of CSB-RA008836A0HU diluted at 1:180 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-RA008836A0HU

Immunofluorescence staining of PC3 cells with CSB-RA008836A0HU at 1:60, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).

Human forkhead box O3,FOXO3 ELISA Kit (CSB-E11177h)

驗(yàn)證數(shù)據(jù)

CSB-E11177h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E11177h

規(guī)格:96T/48T

靈敏度:0.39 pg/mL

檢測(cè)范圍:1.56 pg/mL-100 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

FOXO3 Antibodies

FOXO3 for Homo sapiens (Human)

FOXO3 Proteins

FOXO3 Proteins for Xenopus laevis (African clawed frog)

FOXO3 Proteins for Mus musculus (Mouse)

FOXO3 Proteins for Homo sapiens (Human)

FOXO3 ELISA Kit

FOXO3 ELISA Kit for Homo sapiens (Human)