GABPA
GABPA,即轉(zhuǎn)錄因子GABPA,別名GA結(jié)合蛋白α亞單位。它是一種由GABPA基因編碼的轉(zhuǎn)錄因子,屬于基本區(qū)域-亮氨酸拉鏈(basic region-leucine zipper, bZip)轉(zhuǎn)錄因子家族成員。GABPA在多種細(xì)胞類型中都有表達(dá),并且在細(xì)胞對(duì)生長因子和神經(jīng)遞質(zhì)的響應(yīng)中發(fā)揮重要作用。GABPA的作用機(jī)制主要是通過識(shí)別并結(jié)合到DNA上的特定序列,即GA結(jié)合位點(diǎn)(GA box),調(diào)控下游基因的轉(zhuǎn)錄。GABPA能夠形成同源二聚體或與其他bZip家族成員形成異源二聚體,進(jìn)而增強(qiáng)或抑制特定基因的表達(dá)。此外,GABPA的活性受到多種信號(hào)通路的調(diào)控,包括cAMP/PKA、MAPK/ERK和PI3K/Akt等。在生物學(xué)意義上,GABPA參與了多種細(xì)胞生命活動(dòng)的調(diào)控,包括細(xì)胞增殖、分化、代謝和凋亡等。GABPA的功能異常與多種疾病有關(guān),尤其是與神經(jīng)系統(tǒng)疾病和腫瘤的發(fā)生發(fā)展密切相關(guān)。例如,在神經(jīng)發(fā)育過程中,GABPA通過調(diào)控神經(jīng)相關(guān)基因的表達(dá),影響神經(jīng)元的分化和突觸的形成。在腫瘤細(xì)胞中,GABPA的異常表達(dá)可能促進(jìn)腫瘤細(xì)胞的增殖和侵襲,使其成為腫瘤治療的潛在靶點(diǎn)。因此,GABPA是細(xì)胞生物學(xué)和疾病研究中的一個(gè)重要轉(zhuǎn)錄因子。
熱銷產(chǎn)品
Recombinant Mouse GA-binding protein alpha chain (Gabpa) (CSB-EP4582MO)
驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
GABPA Antibody (CSB-PA22769A0Rb)
驗(yàn)證數(shù)據(jù)

IHC image of CSB-PA22769A0Rb diluted at 1:200 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA22769A0Rb diluted at 1:200 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of Hela cells with CSB-PA22769A0Rb at 1:67, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
GABPA Antibodies
GABPA for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA22769A0Rb | GABPA Antibody | Human | ELISA, IHC, IF |
CSB-PA22769B0Rb | GABPA Antibody, HRP conjugated | Human | ELISA |
CSB-PA22769D0Rb | GABPA Antibody, Biotin conjugated | Human | ELISA |