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GHSR

GHS-R,即生長激素促釋放激素受體,別名Growth hormone secretagogue receptor type 1、GHS-R、GH-releasing peptide receptor。它是一種G蛋白偶聯(lián)受體,主要在大腦、胃腸道和胰腺等組織中表達。GHS-R的作用機制是通過與生長激素促釋放激素(GHRH)結(jié)合,激活Gαs蛋白,進而促進腺苷酸環(huán)化酶(AC)的活性,導致cAMP水平上升,激活蛋白激酶A(PKA),最終促進生長激素(GH)的釋放。它不僅參與調(diào)節(jié)生長激素的分泌,影響生長發(fā)育,還與能量代謝、食欲控制、應(yīng)激反應(yīng)等多種生理過程有關(guān)。此外,GHS-R的活性也與某些疾病相關(guān),例如肥胖和生長激素缺乏癥。因此,GHS-R是內(nèi)分泌學和代謝疾病研究中的一個重要靶點,針對GHS-R的藥物開發(fā)有助于治療相關(guān)疾病。

熱銷產(chǎn)品

GHSR Antibody (CSB-PA450853)

驗證數(shù)據(jù)

CSB-PA450853

Western blot analysis of 1) Rat LiverTissue, 2)Jurkat with Ghrelin Receptor Rabbit pAb diluted at 1:2,000.

CSB-PA450853

Immunohistochemical analysis of paraffin-embedded Human BrainTissue using Ghrelin Receptor Rabbit pAb diluted at 1:200.

CSB-PA450853

Immunohistochemical analysis of paraffin-embedded Human Skin Tissue using Ghrelin Receptor Rabbit pAb diluted at 1:200.

GHSR Antibodies

GHSR for Homo sapiens (Human)

GHSR Proteins

GHSR Proteins for Oryctolagus cuniculus (Rabbit)

GHSR Proteins for Mustela putorius furo (European domestic ferret) (Mustela furo)

GHSR Proteins for Rattus norvegicus (Rat)

GHSR Proteins for Homo sapiens (Human)

GHSR Proteins for Sus scrofa (Pig)

GHSR Proteins for Mus musculus (Mouse)