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GPER1

G-protein coupled estrogen receptor 1 is a protein in humans that is encoded by GPER1 gene. G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation.

GPER1 Antibodies

GPER1 for Homo sapiens (Human)

GPER1 Proteins

GPER1 Proteins for Rattus norvegicus (Rat)

GPER1 Proteins for Mus musculus (Mouse)

GPER1 Proteins for Homo sapiens (Human)