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GPNMB

跨膜糖蛋白GPNMB全稱為黑色素瘤非轉(zhuǎn)移性糖蛋白B，常被稱為骨激活素或樹突狀細(xì)胞相關(guān)跨膜蛋白。GPNMB廣泛分布于黑色素細(xì)胞、破骨細(xì)胞及免疫細(xì)胞表面，主要參與細(xì)胞間識別與微環(huán)境調(diào)控，其異常表達(dá)常伴隨腫瘤侵襲性增強(qiáng)和免疫逃逸現(xiàn)象。GPNMB在超過40%的三陰性乳腺癌和惡性黑色素瘤中過度活躍，其介導(dǎo)的促存活信號可能加速腫瘤轉(zhuǎn)移。在神經(jīng)退行性疾病領(lǐng)域，該蛋白與β淀粉樣蛋白存在相互作用，可能影響阿爾茨海默病的病理進(jìn)程。目前全球有多款靶向GPNMB的藥物進(jìn)入臨床階段，其中抗體偶聯(lián)藥物CDX-011在轉(zhuǎn)移性乳腺癌的Ⅱ期試驗中顯示出可控安全性，新型雙抗藥物GT-002則通過阻斷GPNMB與整合素結(jié)合來抑制骨肉瘤生長。某些小分子抑制劑已證實可穿透血腦屏障，為神經(jīng)相關(guān)疾病的治療開辟了新方向。

熱銷產(chǎn)品

GPNMB Recombinant Monoclonal Antibody (CSB-RA622928MA1HU)

驗證數(shù)據(jù)

Overlay Peak curve showing Hela cells stained with CSB-RA622928MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10⁶cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*10⁶cells) used under the same conditions. Acquisition of >10, 003 events was performed.

Human Transmembrane glycoprotein NMB(GPNMB) ELISA kit (CSB-EL009727HU)

驗證數(shù)據(jù)

貨號：CSB-EL009727HU

規(guī)格：96T/48T

靈敏度：0.195 ng/mL

檢測范圍：0.78 ng/mL-50 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

GPNMB Antibody

GPNMB Protein

GPNMB ELISA Kit

GPNMB Antibodies

GPNMB for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA009727GA01HU	GPNMB Antibody	Human,Mouse	ELISA,IHC
CSB-RA622928MA1HU	GPNMB Recombinant Monoclonal Antibody	Human	ELISA, FC

GPNMB Proteins

GPNMB Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP622928HU CSB-EP622928HU CSB-BP622928HU CSB-MP622928HU CSB-EP622928HU-B	Recombinant Human Transmembrane glycoprotein NMB (GPNMB), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

GPNMB Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP740736RA CSB-EP740736RA CSB-BP740736RA CSB-MP740736RA CSB-EP740736RA-B	Recombinant Rat Transmembrane glycoprotein NMB (Gpnmb), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

GPNMB Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP860839MO CSB-EP860839MO CSB-BP860839MO CSB-MP860839MO CSB-EP860839MO-B	Recombinant Mouse Transmembrane glycoprotein NMB (Gpnmb), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

GPNMB ELISA Kit

GPNMB ELISA Kit for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	樣本類型	靈敏度
CSB-EL009727HU	Human Transmembrane glycoprotein NMB(GPNMB) ELISA kit	serum, plasma, tissue homogenates	0.195 ng/mL
CSB-EL009727HU-IS	Human Transmembrane glycoprotein NMB(GPNMB) ELISA kit	serum, plasma, tissue homogenates, cell culture supernates	0.039 ng/mL