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GREM1

GREM1,全稱為 Gremlin-1,是一種富含半胱氨酸的分泌蛋白,在器官形成和發(fā)育中起關(guān)鍵作用。它也被稱為 BMP ANTAGONIST 1、DRM、LD、IHG-2、MPSH、MGC126660、HOMOLOG 等別名。GREM1 蛋白主要通過抑制骨形態(tài)發(fā)生蛋白(BMP)信號(hào)通路來發(fā)揮作用,從而參與調(diào)控胚胎時(shí)期骨組織、腎臟等重要器官的發(fā)育。它在腫瘤研究中也具有重要意義,GREM1 蛋白在多種癌癥中高表達(dá),與不良預(yù)后相關(guān),被認(rèn)為是腫瘤進(jìn)展的促進(jìn)因子。目前,針對(duì) GREM1 蛋白的藥物研發(fā)正在積極進(jìn)行中,旨在通過抑制 GREM1 蛋白的活性來治療癌癥。

熱銷產(chǎn)品

GREM1 Antibody (CSB-PA009892LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA009892LA01HU

IHC image of CSB-PA009892LA01HU diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA009892LA01HU

IHC image of CSB-PA009892LA01HU diluted at 1:300 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human Gremlin-1(GREM1) ELISA kit (CSB-EL009892HU)

驗(yàn)證數(shù)據(jù)

CSB-EL009892HU 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-EL009892HU

規(guī)格:96T/48T

靈敏度:0.039 ng/mL

檢測(cè)范圍:0.156 ng/mL-10 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

GREM1 Antibodies

GREM1 for Homo sapiens (Human)

GREM1 Proteins

GREM1 Proteins for Homo sapiens (Human)

GREM1 ELISA Kit

GREM1 ELISA Kit for Homo sapiens (Human)