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GSK3B

GSK3B,全稱為Glycogen synthase kinase-3 beta,是一種廣泛存在于哺乳動物細(xì)胞中的絲氨酸/蘇氨酸蛋白激酶。該蛋白在細(xì)胞內(nèi)發(fā)揮著多種生物學(xué)功能,包括調(diào)節(jié)細(xì)胞分化、胚胎發(fā)育、炎癥反應(yīng)和細(xì)胞周期等。GSK3B通過磷酸化多種底物蛋白來調(diào)控這些過程,其常見的底物包括微管相關(guān)蛋白Tau、β-連環(huán)蛋白和環(huán)磷酸腺苷等。此外,GSK3B的活性也受到多種激酶的調(diào)控,例如蛋白激酶C和蛋白激酶A等。
GSK3B與多種疾病密切相關(guān),其中最著名的是阿爾茨海默病。在阿爾茨海默病患者的大腦中,GSK3B的表達(dá)水平升高,且其活性增強(qiáng),這導(dǎo)致了Aβ異常聚集、Tau蛋白過度磷酸化、神經(jīng)細(xì)胞凋亡和炎癥反應(yīng)等病理過程。因此,GSK3B被認(rèn)為是治療阿爾茨海默病的重要靶點(diǎn)。目前,已有多種GSK3B抑制劑被研發(fā)出來,如靛玉紅、鋰鹽等,這些抑制劑能夠有效降低GSK3B的活性,從而改善阿爾茨海默病的癥狀。此外,GSK3B在其他疾病中也發(fā)揮著重要作用,如腫瘤、炎癥和神經(jīng)系統(tǒng)疾病等。針對GSK3B的藥物研發(fā)仍在進(jìn)行中,未來有望為這些疾病的治療提供新的策略。

熱銷產(chǎn)品

Recombinant Human Glycogen synthase kinase-3 beta (GSK3B) (CSB-EP009963HUe2)

驗(yàn)證數(shù)據(jù)

CSB-EP009963HUe2

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

GSK3B Recombinant Monoclonal Antibody (CSB-RA216259A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA216259A0HU

Western Blot
Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate, 293 whole cell lysate
All lanes: GSK3 beta Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 47, 49 kDa
Observed band size: 47 kDa

CSB-RA216259A0HU

IHC image of CSB-RA216259A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA216259A0HU

Immunofluorescence staining of Hela Cells with CSB-RA216259A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

GSK3B Antibodies

GSK3B for Homo sapiens (Human)

GSK3B Proteins

GSK3B Proteins for Rattus norvegicus (Rat)

GSK3B Proteins for Homo sapiens (Human)

GSK3B Proteins for Spermophilus citellus (European suslik) (Citellus citellus)

GSK3B Proteins for Xenopus laevis (African clawed frog)

GSK3B Proteins for Mus musculus (Mouse)