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GUCY2C

GUCY2C,即鳥苷酸環(huán)化酶2C,別名GC-C、STaR、DIAR6、GUC2C、MECIL、MUCIL等。這是一種在人體中由GUCY2C基因編碼的跨膜蛋白,屬于受體鳥苷酸環(huán)化酶家族。GUCY2C主要在腸上皮細(xì)胞中表達(dá),其蛋白結(jié)構(gòu)由細(xì)胞外配體結(jié)合結(jié)構(gòu)域、跨膜結(jié)構(gòu)域、細(xì)胞質(zhì)結(jié)構(gòu)域、催化區(qū)和羧基末端區(qū)域組成。GUCY2C的作用機(jī)制是通過(guò)其配體,如鳥苷素、尿鳥苷素以及熱穩(wěn)定性腸毒素STa的結(jié)合,激活GUCY2C,進(jìn)而催化細(xì)胞內(nèi)第二信使環(huán)磷酸鳥苷(cGMP)的產(chǎn)生,這一過(guò)程在調(diào)節(jié)體內(nèi)平衡、維持腸道屏障功能和發(fā)揮抗炎作用中發(fā)揮重要作用。GUCY2C的異常表達(dá)與多種疾病相關(guān),包括家族性腹瀉、胎糞性腸梗阻、結(jié)直腸癌等。

熱銷產(chǎn)品

Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) (CSB-MP010053HUd9)

驗(yàn)證數(shù)據(jù)

CSB-MP010053HUd9

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP010053HUd9

Activity
Measured by its binding ability in a functional ELISA. Immobilized human GUCY2C at 5 μg/ml can bind Anti-GUCY2C recombinant antibody (CSB-RA010053A2HU), the EC50 is 3.049-4.660 ng/mL.

GUCY2C Recombinant Monoclonal Antibody (CSB-RA010053A3HU)

驗(yàn)證數(shù)據(jù)

CSB-RA010053A3HU

The Binding Activity of Human GUCY2C with Anti-GUCY2C recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GUCY2C (CSB-MP010053HU) at 5 μg/mL can bind Anti-GUCY2C recombinant antibody, the EC50 is 5.630-9.996 ng/mL.

CSB-RA010053A3HU

T84 cells were stained with Human IgG (green line) and anti-GUCY2C antibody (red line) (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-RA010053A3HU

Untransfected CT26 cells surface (green line) and transfected Human GUCY2C CT26 stable cells surface (red line) were stained with anti-GUCY2C antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

GUCY2C Antibodies

GUCY2C for Homo sapiens (Human)

GUCY2C Proteins

GUCY2C Proteins for Cavia porcellus (Guinea pig)

GUCY2C Proteins for Rattus norvegicus (Rat)

GUCY2C Proteins for Sus scrofa (Pig)

GUCY2C Proteins for Homo sapiens (Human)

GUCY2C Proteins for Mus musculus (Mouse)