GYS1
GYS1，即肌肉型糖原合酶。GYS1的活性受到多種因素的精細(xì)調(diào)控，特別是胰島素信號(hào)通路的激活可以促進(jìn)其磷酸化，進(jìn)而提高酶的活性，加強(qiáng)糖原的合成。此外，GYS1還受到AMPK（AMP激活的蛋白激酶）等其他信號(hào)分子的影響，確保在能量需求變化時(shí)能夠迅速調(diào)整糖原的合成速率。在生理學(xué)上，GYS1對(duì)于維持肌肉組織的能量?jī)?chǔ)備、支持運(yùn)動(dòng)能力以及調(diào)節(jié)全身血糖水平都至關(guān)重要。當(dāng)GYS1功能出現(xiàn)障礙時(shí)，可能會(huì)導(dǎo)致糖原積累異常，影響肌肉功能，甚至與某些代謝性疾病的發(fā)展有關(guān)，例如2型糖尿病。深入理解GYS1的作用機(jī)制及其在疾病中的角色，對(duì)于開(kāi)發(fā)新的治療方法具有重要意義。
熱銷(xiāo)產(chǎn)品
Phospho-GYS1 (S641) Recombinant Monoclonal Antibody (CSB-RA010078A641phHU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in Hela whole cell lysate,HepG2 whole cell lysate(treated with Calyculin A or EGF)
All lanes Phospho-GYS1 antibody at 1.12μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 85 KDa
Observed band size: 85 KDa
Immunofluorescence staining of HepG2 cells with CSB-RA010078A641phHU at 1:100,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
GYS1 Antibodies
GYS1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA010078GA01HU | GYS1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA568101 | Phospho-GYS1 (Ser645) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA009060 | Phospho-GYS1 (S641) Antibody | Human,Mouse | WB, ELISA |
| CSB-PA009063 | Phospho-GYS1 (S645) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA009067 | GYS1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA009070 | GYS1 Antibody | Human,Mouse | WB, ELISA |
| CSB-PA985220 | GYS1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA170597 | GYS1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-RA010078A641phHU | Phospho-GYS1 (S641) Recombinant Monoclonal Antibody | Human | ELISA, WB, IF |
GYS1 Proteins
GYS1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP010078HU CSB-EP010078HU CSB-BP010078HU CSB-MP010078HU CSB-EP010078HU-B |
Recombinant Human Glycogen [starch] synthase, muscle (GYS1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GYS1 Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP010078RB CSB-EP010078RB CSB-BP010078RB CSB-MP010078RB CSB-EP010078RB-B |
Recombinant Rabbit Glycogen [starch] synthase, muscle (GYS1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GYS1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP010078BO CSB-EP010078BO CSB-BP010078BO CSB-MP010078BO CSB-EP010078BO-B |
Recombinant Bovine Glycogen [starch] synthase, muscle (GYS1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GYS1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP383396RA CSB-EP383396RA CSB-BP383396RA CSB-MP383396RA CSB-EP383396RA-B |
Recombinant Rat Glycogen [starch] synthase, muscle (Gys1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GYS1 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP722357PYX CSB-EP722357PYX CSB-BP722357PYX CSB-MP722357PYX CSB-EP722357PYX-B |
Recombinant Pongo abelii Glycogen [starch] synthase, muscle (GYS1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GYS1 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP818648MOW CSB-EP818648MOW CSB-BP818648MOW CSB-MP818648MOW CSB-EP818648MOW-B |
Recombinant Macaca mulatta Glycogen [starch] synthase, muscle (GYS1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
