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HIPK2

HIPK2,即同源結(jié)構(gòu)域相互作用蛋白激酶2,別名PRO0593、hHIPk2。HIPK2是一種絲氨酸/蘇氨酸激酶,屬于同源結(jié)構(gòu)域相互作用蛋白激酶家族。HIPK2與同源結(jié)構(gòu)域轉(zhuǎn)錄因子和許多其他轉(zhuǎn)錄因子(如p53)相互作用,可以根據(jù)轉(zhuǎn)錄因子及其亞細(xì)胞定位同時充當(dāng)共抑制因子和共激活因子。HIPK2可以誘導(dǎo)或抑制轉(zhuǎn)錄,調(diào)節(jié)細(xì)胞分化、增殖及凋亡。HIPK2經(jīng)過泛素化、小泛素樣修飾(SUMO)化、乙?;?、磷酸化等翻譯后修飾來發(fā)揮其生物功能。HIPK2能促進(jìn)細(xì)胞凋亡,是潛在的腫瘤抑制因子和DNA損傷相關(guān)激酶,通過磷酸化反應(yīng)作用于不同的下游靶點(diǎn)來激活凋亡進(jìn)程。HIPK2還參與組織器官的形成、腫瘤的發(fā)生和發(fā)展。

熱銷產(chǎn)品

HIPK2 Antibody (CSB-PA867138LA01HU)

驗證數(shù)據(jù)

CSB-PA867138LA01HU

IHC image of CSB-PA867138LA01HU diluted at 1:500 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA867138LA01HU

IHC image of CSB-PA867138LA01HU diluted at 1:500 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

HIPK2 Antibodies

HIPK2 for Homo sapiens (Human)

HIPK2 Proteins

HIPK2 Proteins for Homo sapiens (Human)

HIPK2 Proteins for Mus musculus (Mouse)

HIPK2 Proteins for Mesocricetus auratus (Golden hamster)